biostudies-literatureFreedman BINIDDK NIH HHSNIMHD NIH HHSAstraZeneca1765-1778https://www.ebi.ac.uk/biostudies/studies/S-EPMC8425659biostudies-literatureUnknown32(7)<h4>Background</h4><i>APOL1</i> variants contribute to the markedly higher incidence of ESKD in Blacks compared with Whites. Genetic testing for these variants in patients with African ancestry who have nephropathy is uncommon, and no specific treatment or management protocol for <i>APOL1</i>-associated nephropathy currently exists.<h4>Methods</h4>A multidisciplinary, racially diverse group of 14 experts and patient advocates participated in a Delphi consensus process to establish practical guidance for clinicians caring for patients who may have <i>APOL1</i>-associated nephropathy. Consensus group members took part in three anonymous voting rounds to develop consensus statements relating to the following: (<i>1</i>) counseling, genotyping, and diagnosis; (<i>2</i>) disease awareness and eJournal of the American Society of Nephrology : JASNDiagnosis, Education, and Care of Patients with <i>APOL1</i>-Associated Nephropathy: A Delphi Consensus and Systematic Review.PMC8425659DP2 DK124891R01 MD016401Divers JRoberts GVFreedman BIBurke WNorris KCGadegbeku CAKopp JBKnight RBlacksher EHall MEJones-Smith TGbadegesin REberhard LKovesdy CPOlabisi OASedor JRfalseDiagnosis, Education, and Care of Patients with <i>APOL1</i>-Associated Nephropathy: A Delphi Consensus and Systematic Review.<h4>Background</h4><i>APOL1</i> variants contribute to the markedly higher incidence of ESKD in Blacks compared with Whites. Genetic testing for these variants in patients with African ancestry who have nephropathy is uncommon, and no specific treatment or management protocol for <i>APOL1</i>-associated nephropathy currently exists.<h4>Methods</h4>A multidisciplinary, racially diverse group of 14 experts and patient advocates participated in a Delphi consensus process to establish practical guidance for clinicians caring for patients who may have <i>APOL1</i>-associated nephropathy. Consensus group members took part in three anonymous voting rounds to develop consensus statements relating to the following: (<i>1</i>) counseling, genotyping, and diagnosis; (<i>2</i>) disease awareness and e2021-01-01T00:00:00Z2021 Jul2026-05-08T01:08:39.014Z2022-07-11T07:06:53.308ZS-EPMC84256593385388710.1681/ASN.202010139910.1681/asn.2020101399