biostudies-literatureGhamkharinejad GCognitive Sciences and Technologies CouncilTarbiat Modares UniversityIran National Science Foundatione0253902https://www.ebi.ac.uk/biostudies/studies/S-EPMC8428970biostudies-literatureUnknown16(9)<h4>Background</h4>ɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.<h4>Objective</h4>The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated. Then hippocampal-dependent tasks named spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Finally, the changes in the expression of hippocampal GABA-A receptors underlying morphine tolerance were also examined.<h4>Methods</h4>Rats were treated with daily morphine injections, with or without distinct contextual pairing. To examine the effect of valproic acid on morphine tolerance expression, valproic acid was pretreated an hour before morphine. Spatial-workPloS oneUnconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits.PMC8428970INSF- 96008684Foolad FJavan MGhamkharinejad GMarashi SHFathollahi YfalseUnconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits.<h4>Background</h4>ɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.<h4>Objective</h4>The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated. Then hippocampal-dependent tasks named spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Finally, the changes in the expression of hippocampal GABA-A receptors underlying morphine tolerance were also examined.<h4>Methods</h4>Rats were treated with daily morphine injections, with or without distinct contextual pairing. To examine the effect of valproic acid on morphine tolerance expression, valproic acid was pretreated an hour before morphine. Spatial-work2021-01-01T00:00:00Z20212026-05-27T23:26:26.254Z2022-02-11T10:58:53.857ZS-EPMC84289703450045310.1371/journal.pone.0253902