{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gong Q"],"funding":["CGH CDC HHS","Centers for Disease Control and Prevention","World Bank Group","ACL HHS","China-Japan Friendship Hospital","Intramural CDC HHS"],"pagination":["2385-2394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8429240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["<h4>Aims</h4>The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels.<h4>Materials and methods</h4>Data were used from the Da Qing Diabetes Prevention Outcome Study, which was a 30-year follow-up of a 6-year randomized trial of lifestyle intervention in 576 people with IGT. We then conducted a post-hoc analysis to compare the efficacy of intervention to reduce the incidence of T2DM and its complications in those with baseline FPG <100 mg/dL and FPG ≥100 mg/dL.<h4>Results</h4>Lifestyle intervention reduced the cumulat"],"journal":["Diabetes, obesity & metabolism"],"pubmed_title":["Efficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study."],"pmcid":["PMC8429240"],"funding_grant_id":["CC999999","5U19GH000636‐05","U19GH000636","U58/CCU424123‐01‐02","U19 GH000636"],"pubmed_authors":["Li G","Da Qing Diabetes Prevention Outcome Study Group","Gong Q","Cheng YJ","Gregg EW","Bennett PH","Wang J","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study.","description":"<h4>Aims</h4>The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels.<h4>Materials and methods</h4>Data were used from the Da Qing Diabetes Prevention Outcome Study, which was a 30-year follow-up of a 6-year randomized trial of lifestyle intervention in 576 people with IGT. We then conducted a post-hoc analysis to compare the efficacy of intervention to reduce the incidence of T2DM and its complications in those with baseline FPG <100 mg/dL and FPG ≥100 mg/dL.<h4>Results</h4>Lifestyle intervention reduced the cumulat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T12:04:42.937Z","creation":"2025-04-04T12:04:42.937Z"},"accession":"S-EPMC8429240","cross_references":{"pubmed":["34212465"],"doi":["10.1111/dom.14481"]}}