biostudies-literatureGong QCGH CDC HHSCenters for Disease Control and PreventionWorld Bank GroupACL HHSChina-Japan Friendship HospitalIntramural CDC HHS2385-2394https://www.ebi.ac.uk/biostudies/studies/S-EPMC8429240biostudies-literatureUnknown23(10)<h4>Aims</h4>The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels.<h4>Materials and methods</h4>Data were used from the Da Qing Diabetes Prevention Outcome Study, which was a 30-year follow-up of a 6-year randomized trial of lifestyle intervention in 576 people with IGT. We then conducted a post-hoc analysis to compare the efficacy of intervention to reduce the incidence of T2DM and its complications in those with baseline FPG <100 mg/dL and FPG ≥100 mg/dL.<h4>Results</h4>Lifestyle intervention reduced the cumulatDiabetes, obesity & metabolismEfficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study.PMC8429240CC9999995U19GH000636‐05U19GH000636U58/CCU424123‐01‐02U19 GH000636Li GDa Qing Diabetes Prevention Outcome Study GroupGong QCheng YJGregg EWBennett PHWang JZhang PfalseEfficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study.<h4>Aims</h4>The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels.<h4>Materials and methods</h4>Data were used from the Da Qing Diabetes Prevention Outcome Study, which was a 30-year follow-up of a 6-year randomized trial of lifestyle intervention in 576 people with IGT. We then conducted a post-hoc analysis to compare the efficacy of intervention to reduce the incidence of T2DM and its complications in those with baseline FPG <100 mg/dL and FPG ≥100 mg/dL.<h4>Results</h4>Lifestyle intervention reduced the cumulat2021-01-01T00:00:00Z2021 Oct2025-04-04T12:04:42.937Z2025-04-04T12:04:42.937ZS-EPMC84292403421246510.1111/dom.14481