{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu Y"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["666-678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8432598"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(7)"],"pubmed_abstract":["<h4>Background</h4>Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.<h4>Objectives</h4>The aim of this study was to prospectively examine associations between lignan intake and CHD risk in U.S. men and women.<h4>Methods</h4>We prospectively followed 214,108 men and women in 3 cohorts who did not have cardiovascular disease or cancer at baseline. Diet was repeatedly assessed using a validated food frequency questionnaire every 2-4 years since baseline.<h4>Results</h4>During 5,517,225 person-years of follow-up, we documented 10,244 CHD cases, including 6,283 nonfatal myocardial infarction and 3,961 fatal CHD cases. In multivariable-adjusted analyses, comparing extreme quintiles, the pooled hazard ratios of CHD were 0.85 (95% CI:"],"journal":["Journal of the American College of Cardiology"],"pubmed_title":["Lignan Intake and Risk of Coronary Heart Disease."],"pmcid":["PMC8432598"],"funding_grant_id":["U01 CA167552","R01 CA138962","P01 CA087969","R01 CA049449","U01 CA176726","R01 DK120870","R01 CA067262","R01 HL034594","R01 HL035464","UM1 CA167552","R01 HL060712","R01 HL088521","UM1 CA186107"],"pubmed_authors":["Wang M","Li Y","Manson JE","Hu Y","Rimm E","Sun Q","Sampson L"],"additional_accession":[]},"is_claimable":false,"name":"Lignan Intake and Risk of Coronary Heart Disease.","description":"<h4>Background</h4>Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.<h4>Objectives</h4>The aim of this study was to prospectively examine associations between lignan intake and CHD risk in U.S. men and women.<h4>Methods</h4>We prospectively followed 214,108 men and women in 3 cohorts who did not have cardiovascular disease or cancer at baseline. Diet was repeatedly assessed using a validated food frequency questionnaire every 2-4 years since baseline.<h4>Results</h4>During 5,517,225 person-years of follow-up, we documented 10,244 CHD cases, including 6,283 nonfatal myocardial infarction and 3,961 fatal CHD cases. In multivariable-adjusted analyses, comparing extreme quintiles, the pooled hazard ratios of CHD were 0.85 (95% CI:","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-26T16:24:58.8Z","creation":"2025-04-06T15:13:25.551Z"},"accession":"S-EPMC8432598","cross_references":{"pubmed":["34384548"],"doi":["10.1016/j.jacc.2021.05.049"]}}