biostudies-literatureHu YNIDDK NIH HHSNHLBI NIH HHSNCI NIH HHS666-678https://www.ebi.ac.uk/biostudies/studies/S-EPMC8432598biostudies-literatureUnknown78(7)<h4>Background</h4>Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.<h4>Objectives</h4>The aim of this study was to prospectively examine associations between lignan intake and CHD risk in U.S. men and women.<h4>Methods</h4>We prospectively followed 214,108 men and women in 3 cohorts who did not have cardiovascular disease or cancer at baseline. Diet was repeatedly assessed using a validated food frequency questionnaire every 2-4 years since baseline.<h4>Results</h4>During 5,517,225 person-years of follow-up, we documented 10,244 CHD cases, including 6,283 nonfatal myocardial infarction and 3,961 fatal CHD cases. In multivariable-adjusted analyses, comparing extreme quintiles, the pooled hazard ratios of CHD were 0.85 (95% CI:Journal of the American College of CardiologyLignan Intake and Risk of Coronary Heart Disease.PMC8432598U01 CA167552R01 CA138962P01 CA087969R01 CA049449U01 CA176726R01 DK120870R01 CA067262R01 HL034594R01 HL035464UM1 CA167552R01 HL060712R01 HL088521UM1 CA186107Wang MLi YManson JEHu YRimm ESun QSampson LfalseLignan Intake and Risk of Coronary Heart Disease.<h4>Background</h4>Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.<h4>Objectives</h4>The aim of this study was to prospectively examine associations between lignan intake and CHD risk in U.S. men and women.<h4>Methods</h4>We prospectively followed 214,108 men and women in 3 cohorts who did not have cardiovascular disease or cancer at baseline. Diet was repeatedly assessed using a validated food frequency questionnaire every 2-4 years since baseline.<h4>Results</h4>During 5,517,225 person-years of follow-up, we documented 10,244 CHD cases, including 6,283 nonfatal myocardial infarction and 3,961 fatal CHD cases. In multivariable-adjusted analyses, comparing extreme quintiles, the pooled hazard ratios of CHD were 0.85 (95% CI:2021-01-01T00:00:00Z2021 Aug2025-04-26T16:24:58.8Z2025-04-06T15:13:25.551ZS-EPMC84325983438454810.1016/j.jacc.2021.05.049