{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burnham NW"],"funding":["NIDA NIH HHS","NIAAA NIH HHS","National Institutes of Health"],"pagination":["108702"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8434995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["196"],"pubmed_abstract":["A growing body of literature implicates noradrenergic (NE) signaling in the modulation of ethanol consumption. However, relatively few studies have detailed specific brain pathways that mediate NE-associated binge-like ethanol consumption. To begin to fill this gap in the literature, male and female C57BL6/J and TH-ires-cre mice underwent pharmacological and chemogenetic testing, respectively, in combination with \"drinking in the dark\" procedures to model binge-like consumption of ethanol or sucrose solutions. First, we showed that intraperitoneal administration of the NE reuptake inhibitor, reboxetine, blunted binge-like ethanol intake in C57BL6/J mice. Chemogenetic activation of locus coeruleus (LC) tyrosine hydroxylase (TH)-expressing neurons blunted binge-like ethanol intake regardless"],"journal":["Neuropharmacology"],"pubmed_title":["Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice."],"pmcid":["PMC8434995"],"funding_grant_id":["R01 AA025809","R01 AA013573","R01 AA022048","AA022048","R37 AA013573","AA013573","AA025809","T32 DA007244"],"pubmed_authors":["Navarro M","Segantine Dornellas AP","Chaimowitz CN","Vis CC","Burnham NW","Thiele TE"],"additional_accession":[]},"is_claimable":false,"name":"Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice.","description":"A growing body of literature implicates noradrenergic (NE) signaling in the modulation of ethanol consumption. However, relatively few studies have detailed specific brain pathways that mediate NE-associated binge-like ethanol consumption. To begin to fill this gap in the literature, male and female C57BL6/J and TH-ires-cre mice underwent pharmacological and chemogenetic testing, respectively, in combination with \"drinking in the dark\" procedures to model binge-like consumption of ethanol or sucrose solutions. First, we showed that intraperitoneal administration of the NE reuptake inhibitor, reboxetine, blunted binge-like ethanol intake in C57BL6/J mice. Chemogenetic activation of locus coeruleus (LC) tyrosine hydroxylase (TH)-expressing neurons blunted binge-like ethanol intake regardless","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-22T21:12:52.781Z","creation":"2025-04-06T03:28:06.206Z"},"accession":"S-EPMC8434995","cross_references":{"pubmed":["34246685"],"doi":["10.1016/j.neuropharm.2021.108702"]}}