biostudies-literatureLiang YMedical Science and Technology Innovation Project of Chinese Academy of Medical SciencesInnovation Team in Yunnan Province3652-3661https://www.ebi.ac.uk/biostudies/studies/S-EPMC8437489biostudies-literatureUnknown17(10)<b>Objective</b>: The aim of the current study was to evaluate immunogenicity and safety levels of human inactivated quadrivalent influenza vaccine (QIV) which includes two A strains (A/H1N1, A/H3N2) and two B lineages (B/Victoria, B/Yamagata) in healthy adults via meta-analysis. <b>Methods</b>: Searches were conducted in PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE databases published in 2011-2020 according to inclusion and exclusion criteria. The purpose was to collect and perform meta-analysis of related randomized clinical trial (RCT) data concerning safety and immunogenicity levels of human QIV compared with inactivated trivalent influenza vaccine (TIV). <b>Results</b>: A total of 9 literatures were included. There was no significant difference in the seroconversion(SCR) aHuman vaccines & immunotherapeuticsImmunogenicity and safety levels of inactivated quadrivalent influenza vaccine in healthy adults via meta-analysis.PMC84374892016-I2M-3-0262020-I2M-2-0142015HC027Jing-Xia GGuo-Yang LNi LMa LLiang YChaolie RZhou JfalseImmunogenicity and safety levels of inactivated quadrivalent influenza vaccine in healthy adults via meta-analysis.<b>Objective</b>: The aim of the current study was to evaluate immunogenicity and safety levels of human inactivated quadrivalent influenza vaccine (QIV) which includes two A strains (A/H1N1, A/H3N2) and two B lineages (B/Victoria, B/Yamagata) in healthy adults via meta-analysis. <b>Methods</b>: Searches were conducted in PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE databases published in 2011-2020 according to inclusion and exclusion criteria. The purpose was to collect and perform meta-analysis of related randomized clinical trial (RCT) data concerning safety and immunogenicity levels of human QIV compared with inactivated trivalent influenza vaccine (TIV). <b>Results</b>: A total of 9 literatures were included. There was no significant difference in the seroconversion(SCR) a2021-01-01T00:00:00Z2021 Oct2025-04-04T07:47:53.099Z2025-04-04T07:47:53.099ZS-EPMC84374893415632210.1080/21645515.2021.1932218