{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Henderson M"],"funding":["Fonds de Recherche du Québec - Santé","Heart and Stroke Foundation of Canada","Canadian Institutes of Health Research","Diabète Québec","CIHR"],"pagination":["e046585"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8438758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["<h4>Introduction</h4>Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (cardiac phenotype, aortic distensibility, endothelial function) in adolescents with T1D and healthy age-matched and sex-matched controls; (2) examine associations between these novel early markers with: (i) lifestyle habits; (ii) adipokines and measures of inflammation; and (iii) markers of oxidative stress among adolescents with T1D and controls, and determine group differences in these associations; (3) explore, across both groups, associa"],"journal":["BMJ open"],"pubmed_title":["CARDEA study protocol: investigating early markers of cardiovascular disease and their association with lifestyle habits, inflammation and oxidative stress in adolescence using a cross-sectional comparison of adolescents with type 1 diabetes and healthy controls."],"pmcid":["PMC8438758"],"funding_grant_id":["366194","G-16-00012590"],"pubmed_authors":["Henderson M","Van Hulst A","Benedetti A","Mathieu ME","Barnett TA","Nuyt AM","Friedrich M","Levy E","Bigras JL","Drapeau V","Pelletier C","Lavoie JC"],"additional_accession":[]},"is_claimable":false,"name":"CARDEA study protocol: investigating early markers of cardiovascular disease and their association with lifestyle habits, inflammation and oxidative stress in adolescence using a cross-sectional comparison of adolescents with type 1 diabetes and healthy controls.","description":"<h4>Introduction</h4>Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (cardiac phenotype, aortic distensibility, endothelial function) in adolescents with T1D and healthy age-matched and sex-matched controls; (2) examine associations between these novel early markers with: (i) lifestyle habits; (ii) adipokines and measures of inflammation; and (iii) markers of oxidative stress among adolescents with T1D and controls, and determine group differences in these associations; (3) explore, across both groups, associa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-09T17:06:19.07Z","creation":"2025-05-29T20:47:22.784Z"},"accession":"S-EPMC8438758","cross_references":{"pubmed":["34497076"],"doi":["10.1136/bmjopen-2020-046585"]}}