biostudies-literatureHenderson MFonds de Recherche du Québec - SantéHeart and Stroke Foundation of CanadaCanadian Institutes of Health ResearchDiabète QuébecCIHRe046585https://www.ebi.ac.uk/biostudies/studies/S-EPMC8438758biostudies-literatureUnknown11(9)<h4>Introduction</h4>Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (cardiac phenotype, aortic distensibility, endothelial function) in adolescents with T1D and healthy age-matched and sex-matched controls; (2) examine associations between these novel early markers with: (i) lifestyle habits; (ii) adipokines and measures of inflammation; and (iii) markers of oxidative stress among adolescents with T1D and controls, and determine group differences in these associations; (3) explore, across both groups, associaBMJ openCARDEA study protocol: investigating early markers of cardiovascular disease and their association with lifestyle habits, inflammation and oxidative stress in adolescence using a cross-sectional comparison of adolescents with type 1 diabetes and healthy controls.PMC8438758366194G-16-00012590Henderson MVan Hulst ABenedetti AMathieu MEBarnett TANuyt AMFriedrich MLevy EBigras JLDrapeau VPelletier CLavoie JCfalseCARDEA study protocol: investigating early markers of cardiovascular disease and their association with lifestyle habits, inflammation and oxidative stress in adolescence using a cross-sectional comparison of adolescents with type 1 diabetes and healthy controls.<h4>Introduction</h4>Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (cardiac phenotype, aortic distensibility, endothelial function) in adolescents with T1D and healthy age-matched and sex-matched controls; (2) examine associations between these novel early markers with: (i) lifestyle habits; (ii) adipokines and measures of inflammation; and (iii) markers of oxidative stress among adolescents with T1D and controls, and determine group differences in these associations; (3) explore, across both groups, associa2021-01-01T00:00:00Z2021 Sep2026-05-09T17:06:19.07Z2025-05-29T20:47:22.784ZS-EPMC84387583449707610.1136/bmjopen-2020-046585