{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Qi Y"],"pubmed_abstract":["Aim
Chinese medicine Danhong injection (DHI) is an effective pharmaceutical preparation for treating cerebral infarction. Our previous study shows that DHI can remarkably reduce the ischemic stroke-induced infarct volume in a dose-dependent manner, but the pharmacological mechanism of the DHI dose-dependent relationship is not clear. Therefore, the dose-dependent efficacy of DHI on cerebral ischemia and the underlying mechanisms were further investigated in this study.Methods
A middle cerebral artery occlusion (MCAO) model was established and the rats were randomly divided into six groups: sham, vehicle, DHI dose-1, DHI dose-2, DHI dose-3, and DHI dose-4. Forty-one metabolites in serum were selected as candidate biomarkers of efficacy phenotypes by the Agilent 1290 rapid-re"],"journal":["Frontiers in neuroscience"],"pagination":["645185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8439200"],"repository":["biostudies-literature"],"pubmed_title":["Dose-Dependent Variation of Synchronous Metabolites and Modules in a Yin/Yang Transformation Model of Appointed Ischemia Metabolic Networks."],"pmcid":["PMC8439200"],"pubmed_authors":["Liu J","Zhou N","Zhang Y","Zhu L","Qi Y","Jiang Q","Li B","Wang Z","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"Dose-Dependent Variation of Synchronous Metabolites and Modules in a Yin/Yang Transformation Model of Appointed Ischemia Metabolic Networks.","description":"Aim
Chinese medicine Danhong injection (DHI) is an effective pharmaceutical preparation for treating cerebral infarction. Our previous study shows that DHI can remarkably reduce the ischemic stroke-induced infarct volume in a dose-dependent manner, but the pharmacological mechanism of the DHI dose-dependent relationship is not clear. Therefore, the dose-dependent efficacy of DHI on cerebral ischemia and the underlying mechanisms were further investigated in this study.Methods
A middle cerebral artery occlusion (MCAO) model was established and the rats were randomly divided into six groups: sham, vehicle, DHI dose-1, DHI dose-2, DHI dose-3, and DHI dose-4. Forty-one metabolites in serum were selected as candidate biomarkers of efficacy phenotypes by the Agilent 1290 rapid-re","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T04:41:06.615Z","creation":"2022-02-11T11:05:00.299Z"},"accession":"S-EPMC8439200","cross_references":{"pubmed":["34531713"],"doi":["10.3389/fnins.2021.645185"]}}