{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["National Institute of Neurological Disorders and Stroke","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["1053-1065"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8440374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(4)"],"pubmed_abstract":["<h4>Background</h4>Disruption of brain oxygen delivery and consumption after hypoxic-ischemic injury contributes to neonatal mortality and neurological impairment. Measuring cerebral hemodynamic parameters, including cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO<sub>2</sub> ), is clinically important.<h4>Purpose</h4>Phase-contrast (PC), velocity-selective arterial spin labeling (VSASL), and T<sub>2</sub> -relaxation-under-phase-contrast (TRUPC) are magnetic resonance imaging (MRI) techniques that have shown promising results in assessing cerebral hemodynamics in humans. We aimed to test their feasibility in quantifying CBF, OEF, and CMRO<sub>2</sub> in piglets.<h4>Study type</h4>Prospective.<h4>Animal model</h4>Ten neonatal piglets"],"journal":["Journal of magnetic resonance imaging : JMRI"],"pubmed_title":["Multi-Parametric Evaluation of Cerebral Hemodynamics in Neonatal Piglets Using Non-Contrast-Enhanced Magnetic Resonance Imaging Methods."],"pmcid":["PMC8440374"],"funding_grant_id":["R01 NS107417","R01 HL144751","R01 NS113921","R01 NS109029"],"pubmed_authors":["Tekes A","Qin Q","Lee JK","Liu P","Martin LJ","Jiang D","Liu D","Kulikowicz E"],"additional_accession":[]},"is_claimable":false,"name":"Multi-Parametric Evaluation of Cerebral Hemodynamics in Neonatal Piglets Using Non-Contrast-Enhanced Magnetic Resonance Imaging Methods.","description":"<h4>Background</h4>Disruption of brain oxygen delivery and consumption after hypoxic-ischemic injury contributes to neonatal mortality and neurological impairment. Measuring cerebral hemodynamic parameters, including cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO<sub>2</sub> ), is clinically important.<h4>Purpose</h4>Phase-contrast (PC), velocity-selective arterial spin labeling (VSASL), and T<sub>2</sub> -relaxation-under-phase-contrast (TRUPC) are magnetic resonance imaging (MRI) techniques that have shown promising results in assessing cerebral hemodynamics in humans. We aimed to test their feasibility in quantifying CBF, OEF, and CMRO<sub>2</sub> in piglets.<h4>Study type</h4>Prospective.<h4>Animal model</h4>Ten neonatal piglets","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T12:04:51.642Z","creation":"2025-04-04T12:04:51.642Z"},"accession":"S-EPMC8440374","cross_references":{"pubmed":["33955613"],"doi":["10.1002/jmri.27638"]}}