{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grant J"],"funding":["Hansjörg Wyss Institute for Biologically Inspired Engineering","National Center for Advancing Translational Sciences","Defense Advanced Research Projects Agency","NHLBI NIH HHS"],"pagination":["3509-3519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8440455"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(18)"],"pubmed_abstract":["Microfluidic organ-on-a-chip (Organ Chip) cell culture devices are often fabricated using polydimethylsiloxane (PDMS) because it is biocompatible, transparent, elastomeric, and oxygen permeable; however, hydrophobic small molecules can absorb to PDMS, which makes it challenging to predict drug responses. Here, we describe a combined simulation and experimental approach to predict the spatial and temporal concentration profile of a drug under continuous dosing in a PDMS Organ Chip containing two parallel channels separated by a porous membrane that is lined with cultured cells, without prior knowledge of its log <i>P</i> value. First, a three-dimensional finite element model of drug loss into the chip was developed that incorporates absorption, adsorption, convection, and diffusion, which s"],"journal":["Lab on a chip"],"pubmed_title":["Simulating drug concentrations in PDMS microfluidic organ chips."],"pmcid":["PMC8440455"],"funding_grant_id":["1-UH3-HL-141797-01","UH3 HL141797","W911NF-16-C-0050","HR0011-19-2-0008/AWD-102840-612"],"pubmed_authors":["Ingber DE","Ozkan A","Prantil-Baun R","Oh C","Mahajan G","Grant J"],"additional_accession":[]},"is_claimable":false,"name":"Simulating drug concentrations in PDMS microfluidic organ chips.","description":"Microfluidic organ-on-a-chip (Organ Chip) cell culture devices are often fabricated using polydimethylsiloxane (PDMS) because it is biocompatible, transparent, elastomeric, and oxygen permeable; however, hydrophobic small molecules can absorb to PDMS, which makes it challenging to predict drug responses. Here, we describe a combined simulation and experimental approach to predict the spatial and temporal concentration profile of a drug under continuous dosing in a PDMS Organ Chip containing two parallel channels separated by a porous membrane that is lined with cultured cells, without prior knowledge of its log <i>P</i> value. First, a three-dimensional finite element model of drug loss into the chip was developed that incorporates absorption, adsorption, convection, and diffusion, which s","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T09:37:18.637Z","creation":"2025-04-04T09:37:18.637Z"},"accession":"S-EPMC8440455","cross_references":{"pubmed":["34346471"],"doi":["10.1039/d1lc00348h"]}}