biostudies-literatureLu YPZhao Yi-Cheng Medical Science Foundation683-696https://www.ebi.ac.uk/biostudies/studies/S-EPMC8443994biostudies-literatureUnknown39(4)<h4>Purpose</h4>We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse prognosis for malignant melanoma (MM) patients.<h4>Materials and methods</h4>The PubMed, Cochrane Library, Web of Science, EMBASE, and ClinicalTrails.gov databases were searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the association between PDE5Is use and risk of skin cancers. Cumulative meta-analysis and trial sequential analysis (TSA) were also conducted. Survival outcomes were analyzed online.<h4>Results</h4>After pooling all 8 eligible studies comprising 7,479,852 subjects, we found that PDE5Is The world journal of men's healthPhosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects.PMC8443994ZYYFY2018031Liu XLiu KYang YLiang ZLu YPWang XKang JFan SZhou KSong YfalsePhosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects.<h4>Purpose</h4>We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse prognosis for malignant melanoma (MM) patients.<h4>Materials and methods</h4>The PubMed, Cochrane Library, Web of Science, EMBASE, and ClinicalTrails.gov databases were searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the association between PDE5Is use and risk of skin cancers. Cumulative meta-analysis and trial sequential analysis (TSA) were also conducted. Survival outcomes were analyzed online.<h4>Results</h4>After pooling all 8 eligible studies comprising 7,479,852 subjects, we found that PDE5Is 2021-01-01T00:00:00Z2021 Oct2025-04-04T19:44:41.261Z2022-02-11T11:31:10.168ZS-EPMC84439943315104310.5534/wjmh.200082