biostudies-literatureZhou WNIA NIH HHSNHLBI NIH HHS93-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC8444062biostudies-literatureUnknown7(1)<h4>Importance</h4>Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) on positron emission tomography (PET) myocardial perfusion imaging may identify adverse myocardial characteristics, including myocardial stress and injury in aortic stenosis (AS).<h4>Objective</h4>To investigate whether MFR and stress MBF are associated with LV structure and function derangements, and whether these parameters improve after aortic valve replacement (AVR).<h4>Design, setting, and participants</h4>In this single-center prospective observational study in Boston, Massachusetts, from 2018 to 2020, patients with predominantly moderate to severe AS underwent ammonia N13 PET myocardial perfusion imaging for myocardial blood flow (MBF) quantification, resting transthoracic echocardiograpJAMA cardiologyAssociation of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study.PMC8444062R01 HL132021K23 HL135438T32 HL094301P30 AG031679Di Carli MFBajaj NSLewis EFTaqueti VRSlomka PBlankstein RChandra AZhou WSun YPHainer JKaneko TGupta AAdler DSDorbala SMorgan VBibbo CFShah PBO'Gara PBarrett LMartell LDivakaran SfalseAssociation of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study.<h4>Importance</h4>Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) on positron emission tomography (PET) myocardial perfusion imaging may identify adverse myocardial characteristics, including myocardial stress and injury in aortic stenosis (AS).<h4>Objective</h4>To investigate whether MFR and stress MBF are associated with LV structure and function derangements, and whether these parameters improve after aortic valve replacement (AVR).<h4>Design, setting, and participants</h4>In this single-center prospective observational study in Boston, Massachusetts, from 2018 to 2020, patients with predominantly moderate to severe AS underwent ammonia N13 PET myocardial perfusion imaging for myocardial blood flow (MBF) quantification, resting transthoracic echocardiograp2022-01-01T00:00:00Z2022 Jan2025-04-22T21:13:21.209Z2025-04-06T03:28:15.719ZS-EPMC84440623452439710.1001/jamacardio.2021.3396