biostudies-literatureColvert GMAmerican Heart AssociationAbbott LaboratoriesNHLBI NIH HHSNational Institutes of HealthNIH HHS410-419https://www.ebi.ac.uk/biostudies/studies/S-EPMC8445197biostudies-literatureUnknown5(4)<h4>Background</h4>Regional left ventricular (LV) mechanics in mitral regurgitation (MR) patients, and local changes in function after transcatheter mitral valve implantation (TMVI) have yet to be evaluated. Herein, we introduce a method for creating high resolution maps of endocardial function from 4DCT images, leading to detailed characterization of changes in local LV function. These changes are particularly interesting when evaluating the effect of the Tendyne^™ TMVI device in the region of the epicardial pad.<h4>Methods</h4>Regional endocardial shortening from CT (RS_CT) was evaluated in Tendyne (Abbott Medical) TMVI patients with 4DCT exams pre- and post-implantation. Regional function was evaluated in 90 LV segments (5 longitudinal × 18 circumferential). LV volumStructural heart : the journal of the Heart TeamNovel 4DCT Method to Measure Regional Left Ventricular Endocardial Shortening Before and After Transcatheter Mitral Valve Implantation.PMC8445197R01 HL144678T32 HL105373K01 HL143113T32HL105373F31 HL15118320PRE35210261S10 OD010417F31HL151183K01HL143113R01HL144678R25 HL145817Yang JManohar ABlanke PContijoch FJMcVeigh ERGlynn JColvert GMLeipsic JAfalseNovel 4DCT Method to Measure Regional Left Ventricular Endocardial Shortening Before and After Transcatheter Mitral Valve Implantation.<h4>Background</h4>Regional left ventricular (LV) mechanics in mitral regurgitation (MR) patients, and local changes in function after transcatheter mitral valve implantation (TMVI) have yet to be evaluated. Herein, we introduce a method for creating high resolution maps of endocardial function from 4DCT images, leading to detailed characterization of changes in local LV function. These changes are particularly interesting when evaluating the effect of the Tendyne^™ TMVI device in the region of the epicardial pad.<h4>Methods</h4>Regional endocardial shortening from CT (RS_CT) was evaluated in Tendyne (Abbott Medical) TMVI patients with 4DCT exams pre- and post-implantation. Regional function was evaluated in 90 LV segments (5 longitudinal × 18 circumferential). LV volum2021-01-01T00:00:00Z20212025-04-05T14:59:12.257Z2025-04-05T14:59:12.257ZS-EPMC84451973454144310.1080/24748706.2021.1934617