biostudies-literatureUnknown11(1)Koduri MAHyderabad Eye Research FoundationTo investigate the differential expression of tear cytokine levels among chronic Stevens-Johnson syndrome (SJS) patients to better understand the role of significantly altered cytokines in disease development. Tear samples were collected using Schirmer strips in 24 eyes of chronic SJS, 24 eyes of age and gender-matched controls, and 14 eyes of aqueous deficiency dry eye disease (DED) patients. The cytokine analysis was performed among 18 analytes which include pro-inflammatory, anti-inflammatory factors, and ELR-negative CXC chemokines. String analysis was performed for the significantly altered cytokines to understand their co-expression and role in the disease development. Additionally, a literature review was conducted to identify the signature cytokines present in chronic SJS tears. ThScientific reports18433https://www.ebi.ac.uk/biostudies/studies/S-EPMC8446064biostudies-literatureDifferential expression of tear film cytokines in Stevens-Johnson syndrome patients and comparative review of literature.PMC8446064Koduri MAPrasad DBasu SUpadhyaya SJaffet JShanbhag SSSingh VfalseDifferential expression of tear film cytokines in Stevens-Johnson syndrome patients and comparative review of literature.To investigate the differential expression of tear cytokine levels among chronic Stevens-Johnson syndrome (SJS) patients to better understand the role of significantly altered cytokines in disease development. Tear samples were collected using Schirmer strips in 24 eyes of chronic SJS, 24 eyes of age and gender-matched controls, and 14 eyes of aqueous deficiency dry eye disease (DED) patients. The cytokine analysis was performed among 18 analytes which include pro-inflammatory, anti-inflammatory factors, and ELR-negative CXC chemokines. String analysis was performed for the significantly altered cytokines to understand their co-expression and role in the disease development. Additionally, a literature review was conducted to identify the signature cytokines present in chronic SJS tears. Th2021-01-01T00:00:00Z2021 Sep2026-05-08T00:13:33.605Z2022-02-11T11:12:58.616ZS-EPMC84460643453143810.1038/s41598-021-97575-y