{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(9)"],"submitter":["Tateyama-Makino R"],"funding":["Lion Corporation"],"pubmed_abstract":["SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after binding to the host angiotensin-converting enzyme 2 (ACE2). Since ACE2 and TMPRSS2 are expressed in the tongue and gingival mucosa, the oral cavity is a potential entry point for SARS-CoV-2. This study evaluated the inhibitory effects of general ingredients of toothpastes and mouthwashes on the spike protein-ACE2 interaction and the TMPRSS2 protease activity using an in vitro assay. Both assays detected inhibitory effects of sodium tetradecene sulfonate, sodium N-lauroyl-N-methyltaurate, sodium N-lauroylsarcosinate, sodium dodecyl sulfate, and copper gluconate. Molecular docking simulations suggested that these ingredients could bind to inhibitor-binding site of ACE2. Fur"],"journal":["PloS one"],"pagination":["e0257705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8448299"],"repository":["biostudies-literature"],"pubmed_title":["The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro."],"pmcid":["PMC8448299"],"pubmed_authors":["Tsukinoki K","Morishita S","Tsutsumi K","Yamamoto Y","Tateyama-Makino R","Abe-Yutori M","Tsuji M","Iwamoto T","Nishinaga E","Kurita K"],"additional_accession":[]},"is_claimable":false,"name":"The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro.","description":"SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after binding to the host angiotensin-converting enzyme 2 (ACE2). Since ACE2 and TMPRSS2 are expressed in the tongue and gingival mucosa, the oral cavity is a potential entry point for SARS-CoV-2. This study evaluated the inhibitory effects of general ingredients of toothpastes and mouthwashes on the spike protein-ACE2 interaction and the TMPRSS2 protease activity using an in vitro assay. Both assays detected inhibitory effects of sodium tetradecene sulfonate, sodium N-lauroyl-N-methyltaurate, sodium N-lauroylsarcosinate, sodium dodecyl sulfate, and copper gluconate. Molecular docking simulations suggested that these ingredients could bind to inhibitor-binding site of ACE2. Fur","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T01:51:42.183Z","creation":"2022-02-11T11:11:46.487Z"},"accession":"S-EPMC8448299","cross_references":{"pubmed":["34534255"],"doi":["10.1371/journal.pone.0257705"]}}