biostudies-literatureChandra DTobacco-Related Disease Research ProgramGlaxoSmithKlineCOPD FoundationNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Institutes of Health858-871https://www.ebi.ac.uk/biostudies/studies/S-EPMC8449003biostudies-literatureUnknown160(3)<h4>Background</h4>Smokers manifest varied phenotypes of pulmonary impairment.<h4>Research question</h4>Which pulmonary phenotypes are associated with coronary artery disease (CAD) in smokers?<h4>Study design and methods</h4>We analyzed data from the University of Pittsburgh COPD Specialized Center for Clinically Oriented Research (SCCOR) cohort (n = 481) and the Genetic Epidemiology of COPD (COPDGene) cohort (n = 2,580). Participants were current and former smokers with > 10 pack-years of tobacco exposure. Data from the two cohorts were analyzed separately because of methodologic differences. Lung hyperinflation was assessed by plethysmography in the SCCOR cohort and by inspiratory and expiratory CT scan lung volumes in the COPDGene cohort. Subclinical CAD was assessed as the coronary artChestThe Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers.PMC8449003RC2 HL101715R01 HL1331371K23HL126912SAP 4100062224R01 HL153400R01 HL149861R01 HL153400-01HL084948R01 HL089856HHSN268201100019C20XT-0014K23 HL126912R01HL089856R01HL089897R01 HL089897P50 HL0849487RC2HL101715Lan CKelsen SDiaz AARuiz MEKinney GLD'Alonzo GRamsdell JRosiello RCordova FRoss JCPutcha NPorszasz JThomashow BBudoff MStrandHughes JComellas APGinneken BVMcEvoy CWashko GJacobson FLSoler XNewell JDQiao DWendt CKunisaki KMBillings JWells JMHorton KBailey WSciurba FDass CKazerooni ERegan EABoueiz ARJudy PFHersh CDransfield MFischer HHayden LPKluiber AAnzueto AMake BJStringer WCastaldi PJNath HDesai PBarr RGSilverman EKBanaei-Kashani FMaselli-Caceres DJacobs MNewell JHan MKMacIntyre NLeader JKLynch DASchroeder JShenoy KCriner GHoffman EAHalper-Stromberg EWeissfeld JBon JSciurba FCHokanson JHumphries SCurtis JLLange CCiccolella DCOPDGene InvestigatorsVan Beek EGray TEverett DGuntupalli KWestney GAustin JStoel BCStinson DAdams SHersh CPWan ESTashjian JYen AKim VRossiter HVega-Sanchez MEHoth KFHetmanski JYoung KAAllen TThompson BMurray SWise RHansel NNLaird NSieren JHokanson JESteiner RMFuhrman CRD'Souza BBhatt SGuy EDeBakey MEGupta ABhatt SPSharafkhaneh AProkopenko DBowler RPKechris KBeaty TAdami AForeman MGPace DCasaburi RPernicano PGWilson CGSan Jose Estepar RWashington LMamary AJParulekar ALutz SMPratte KBowler RBegum FIyer ASakornsakolpat PLambert ABerkowitz EFuhrman CMartinez CParker MMDeMeo DLFriedman Pvan Rikxoort EKinney GCoxson HOKazerooni EAHobbs BDBoriek AChandra DMarchetti NCrapo JDCho MWon SSatti ABegnaud AAtik MTschirren JJensen RMcAdams HPMcDonald MLAl Qaisi MBell BCrooks JHanania NSwift IMoore CSwift ABrown RMartinez CHfalseThe Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers.<h4>Background</h4>Smokers manifest varied phenotypes of pulmonary impairment.<h4>Research question</h4>Which pulmonary phenotypes are associated with coronary artery disease (CAD) in smokers?<h4>Study design and methods</h4>We analyzed data from the University of Pittsburgh COPD Specialized Center for Clinically Oriented Research (SCCOR) cohort (n = 481) and the Genetic Epidemiology of COPD (COPDGene) cohort (n = 2,580). Participants were current and former smokers with > 10 pack-years of tobacco exposure. Data from the two cohorts were analyzed separately because of methodologic differences. Lung hyperinflation was assessed by plethysmography in the SCCOR cohort and by inspiratory and expiratory CT scan lung volumes in the COPDGene cohort. Subclinical CAD was assessed as the coronary art2021-01-01T00:00:00Z2021 Sep2025-04-04T09:36:51.887Z2025-04-04T09:36:51.887ZS-EPMC84490033397114410.1016/j.chest.2021.04.066