{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Utzschneider KM"],"funding":["BLRD VA","NCATS NIH HHS","Centers for Disease Control and Prevention","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Heart, Lung, and Blood Institute","American Diabetes Association","NIGMS NIH HHS"],"pagination":["e002264"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8449940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["<h4>Introduction</h4>The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.<h4>Research design and methods</h4>This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed <10 years who underwent 2-hour 75 g OGTT at baseline as part of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (G"],"journal":["BMJ open diabetes research & care"],"pubmed_title":["Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin."],"pmcid":["PMC8449940"],"funding_grant_id":["N/A","UL1 TR002378","UL1 TR002537","UL1 TR001425","UL1 TR002535","UL1 TR000439","UL1 TR001108","UL1 TR001449","I01 BX005831","UL1 TR001409","P30 DK020572","P30 DK124723","UL1 TR002243","P30 DK092926","UL1 TR002489","UL1 TR002345","UL1 TR002548","P30 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A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.<h4>Research design and methods</h4>This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed <10 years who underwent 2-hour 75 g OGTT at baseline as part of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (G","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-06-16T03:12:05.7Z","creation":"2026-06-16T03:07:06.22Z"},"accession":"S-EPMC8449940","cross_references":{"pubmed":["34531242"],"doi":["10.1136/bmjdrc-2021-002264"]}}