biostudies-literatureUtzschneider KMBLRD VANCATS NIH HHSCenters for Disease Control and PreventionNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteAmerican Diabetes AssociationNIGMS NIH HHSe002264https://www.ebi.ac.uk/biostudies/studies/S-EPMC8449940biostudies-literatureUnknown9(1)<h4>Introduction</h4>The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.<h4>Research design and methods</h4>This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed <10 years who underwent 2-hour 75 g OGTT at baseline as part of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GBMJ open diabetes research & careShape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin.PMC8449940N/AUL1 TR002378UL1 TR002537UL1 TR001425UL1 TR002535UL1 TR000439UL1 TR001108UL1 TR001449I01 BX005831UL1 TR001409P30 DK020572P30 DK124723UL1 TR002243P30 DK092926UL1 TR002489UL1 TR002345UL1 TR002548P30 DK017047U54 GM104940UL1 TR000445UL1 TR002529P30 DK097512U34 DK088043P30 DK072476U01 DK098246P30 DK079626P30 DK020541Hamm MEstrada LTaylor WCulmer DAlfred AGaba RPatel CHazlett CSchield EPetrovitch HUtzschneider KMPatel NAlfano LRassouli NLaSalle EGonzalez EVRessing AKuechenmeister LDeManbey AWright CBurgess EKimpel JBStancil KALesne LCraig JMech MMaher-Albertelli MGurry LGullett CPerson SOropesa-Gonzalez LWaltje ABallentine-Cargill KHurtado MSatterwhite BMGonzalez ERiera GSeaquist ERFalck-Ytter CNieto-Martinez RYoung LSanders CTsovian MHoward DGarcia-Acosta DKarshner TShivaswamy VMartens TTillson RHerson MJenkins VCherrington AHamilton TMofor FJosephson DHFrances SAugust PBerame KRoss ACurtis JMYamashita DHillard MCoffer STanukonda SHenry RTan MHMorton SRodriguez MGKulow TKirpitch AJoarder FKirkman MSHill RBoeder SMontes GPassi RXhori EDulin HChatterjee RBroadwater LFraser RYepes MCoe MChionh KWexler DJBrown-Friday JEllis ERocchio GNelson RTiktin MDostou JBantle AKuhn AKrol ASavoye LLoveland AEggleston RThomas LLMartinez JBuse JBOlson DGoncharova ALachin JMSanders-Jones CRamey PAPanos EEnglish Jones JAlmeida HJones SHsia DSGreenway FLSood AArnold KJohnson MGumpel KBarzilay JIPhillips LSKolli AJensen CBastawrose JMaggio CKauffman BCayford MHarindhanavudhi TBermudez NOWhitley KAdducci JRaskin PJackson AMeigs JEggert JRaymond EKillean TKhalid MCady NPring JSchell KBantle JKleeberger KAbouAssi HGoodhall LJackson MKochis RLukin JAby-Daniel DBergenstal REl-Haqq ZMartin DMcConnell JMartin CMarks JGlauber HHernandez SCherian AVonder Meulen MBJosey KSahnow SStevens CKrakoff JDushkin ALipp SWilson PCastro EHaynes NGuarda SSprague CKringas PKahn SELarkin MBurge MMartin KDeLue CBergamo KWhite CAWerner AMungara RBule SCefalu WTCramer BHurt SAdolphe AKerr JSmiley AFurst MStokes KHue LKirchhoff PJoshevama EYounes NBourgeois BAsh BSteiner SHyatt JRipley VTaddese ACook JNazarov SMcCullars SLteif ASayyed Kassem LGarvey WTLorch RRogge MCSteiner BKersey KAhmann AWaguespack CKessler NFeinglos MNLee MGolson DBoers JPuttnam ROjoawo BKuo SSibymon MRobertson MCChu KSchroeder EGoley AGluth JDebnam EAdams CMatwichyna MHausheer CDesouza CCarlson CHolloway LValencia WMKononets MVCarlson ACurtis MMaggs SWilson CKatona ATran TGutt MKiker LMudaliar SGoland RRoe EFlorez HJGreen JBAlbu JBarzilay JMadden MMorimoto VIsmail-Beigi FGRADE Research GroupHollander PMishko MMBaker CBalasubramanyam ABays KAMaxwell GMRedmon BHox SHCline EGarg RAgne AKunkel SColosimo LCostello JMcKee MDAguillar DCuffee JLargay JFLowe TPettus JBurt PHollis BPark JRivera-Eschright NWillis HMorehead FHerman WHSivitz WKhan SAIshii RRWexler DUnderkofler CBrown NMTorgrimson-Ojerio BGriffith OPi-Sunyer FXBanerji MACriscola JDiaz EYang SMullen MDuran-Valdez EKonerza WDuran SMariash CNCasula SIacoboni JThangthaeng NEstrella HSchade DSFriason CBehringer-Massera SChambers BCohen RMGonzalez de la Torre SGong XEvans Kreider KSchneier HNewman CDouglass SFortmann STsingine KRaines TSCrandall JPJacobson MHThomassie ARasouli NPop-Busui RRiccio Veliz AKKing ELorber DMularski KPrihoda JKnosp LTejada JGhazi ARhee MSmith SThacker CRSeipel KZimmer RPMorales ALAroda VMorales Gomez BFuller GTucker LPirics VKumar ALord GGhioni DMather KJfalseShape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin.<h4>Introduction</h4>The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.<h4>Research design and methods</h4>This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed <10 years who underwent 2-hour 75 g OGTT at baseline as part of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (G2021-01-01T00:00:00Z2021 Sep2026-06-16T03:12:05.7Z2026-06-16T03:07:06.22ZS-EPMC84499403453124210.1136/bmjdrc-2021-002264