{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Towner TT"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NIAAA NIH HHS"],"pagination":["11-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8451018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91"],"pubmed_abstract":["The brain undergoes substantial maturation during adolescence, and repeated exposure to ethanol at this time has been shown to result in long-lasting behavioral and neural consequences. During the broad period of adolescence, different neuronal populations and circuits are refined between early and late adolescence, suggesting the possibility that ethanol exposure at these differing times may lead to differential outcomes. The goal of the current study was to evaluate the impact of adolescent intermittent ethanol (AIE) during early and late adolescence on the formation of goal-directed and habitual behavior in adulthood. Male and female Sprague-Dawley rats were exposed to ethanol via intragastric gavage (4.0 g/kg, 25% v/v) every other day from postnatal day (P) 25-45 or P45-65, considered "],"journal":["Alcohol (Fayetteville, N.Y.)"],"pubmed_title":["Rats exposed to intermittent ethanol during late adolescence exhibit enhanced habitual behavior following reward devaluation."],"pmcid":["PMC8451018"],"funding_grant_id":["T32 AA025606","U01 AA019972"],"pubmed_authors":["Towner TT","Spear LP"],"additional_accession":[]},"is_claimable":false,"name":"Rats exposed to intermittent ethanol during late adolescence exhibit enhanced habitual behavior following reward devaluation.","description":"The brain undergoes substantial maturation during adolescence, and repeated exposure to ethanol at this time has been shown to result in long-lasting behavioral and neural consequences. During the broad period of adolescence, different neuronal populations and circuits are refined between early and late adolescence, suggesting the possibility that ethanol exposure at these differing times may lead to differential outcomes. The goal of the current study was to evaluate the impact of adolescent intermittent ethanol (AIE) during early and late adolescence on the formation of goal-directed and habitual behavior in adulthood. Male and female Sprague-Dawley rats were exposed to ethanol via intragastric gavage (4.0 g/kg, 25% v/v) every other day from postnatal day (P) 25-45 or P45-65, considered ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:58:23.991Z","creation":"2025-04-04T19:58:23.991Z"},"accession":"S-EPMC8451018","cross_references":{"pubmed":["33031883"],"doi":["10.1016/j.alcohol.2020.09.004"]}}