{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Custodio RJP"],"funding":["National Research Foundation of Korea"],"pagination":["1101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8452653"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(1)"],"pubmed_abstract":["Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, potentially with a biological basis; however, its exact cause remains unknown. Thyroid hormone (TH) abnormalities are more prevalent in patients with ADHD than in the general population, indicating a shared pathogenetic mechanism for these conditions. Previously, we identified that overexpression of thyroid hormone-responsive protein (THRSP), a gene highly responsive to TH status, induced inattention in male mice. Herein, we sought to explore whether TH function in THRSP-overexpressing (THRSP OE) mice influences ADHD-like (inattention) behavior. We now confirm that THRSP overexpression in male mice reproduces behavioral features of ADHD, including sustained inattention and memory impairment, accompanied by ex"],"journal":["Communications biology"],"pubmed_title":["Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein."],"pmcid":["PMC8452653"],"funding_grant_id":["2016R1D1A1B02010387; 2020M3E5D9080791"],"pubmed_authors":["Sayson LV","Ortiz DM","Kim HJ","Cheong JH","Custodio RJP","Kim BN","Lee HJ","Kim M"],"additional_accession":[]},"is_claimable":false,"name":"Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein.","description":"Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, potentially with a biological basis; however, its exact cause remains unknown. Thyroid hormone (TH) abnormalities are more prevalent in patients with ADHD than in the general population, indicating a shared pathogenetic mechanism for these conditions. Previously, we identified that overexpression of thyroid hormone-responsive protein (THRSP), a gene highly responsive to TH status, induced inattention in male mice. Herein, we sought to explore whether TH function in THRSP-overexpressing (THRSP OE) mice influences ADHD-like (inattention) behavior. We now confirm that THRSP overexpression in male mice reproduces behavioral features of ADHD, including sustained inattention and memory impairment, accompanied by ex","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-06-12T04:02:56.41Z","creation":"2022-02-11T11:47:05.805Z"},"accession":"S-EPMC8452653","cross_references":{"pubmed":["34545202"],"doi":["10.1038/s42003-021-02633-w"]}}