{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rhea EM"],"funding":["NIA NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["18636"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8452709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Age, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer's disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been investigated. Central nervous system (CNS) insulin resistance is commonly involved in each of these risk factors. CNS insulin is primarily derived from the periphery in which insulin must be transported across the blood-brain barrier (BBB). Additionally, insulin can bind the brain endothelial cell to affect intracellular signaling. Therefore, we hypothesized CNS access to insulin could be affected by the combination of apoE isoform, sex, and diet. We analyzed insulin BBB pharmacokinetics in aged apoE targeted "],"journal":["Scientific reports"],"pubmed_title":["Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice."],"pmcid":["PMC8452709"],"funding_grant_id":["T32 AG055378","RF1 AG059088","RF1AG059088","P30 AG066509"],"pubmed_authors":["Torres ERS","Pemberton S","Raber J","Rhea EM","Banks WA","Hansen K","Holden S"],"additional_accession":[]},"is_claimable":false,"name":"Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice.","description":"Age, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer's disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been investigated. Central nervous system (CNS) insulin resistance is commonly involved in each of these risk factors. CNS insulin is primarily derived from the periphery in which insulin must be transported across the blood-brain barrier (BBB). Additionally, insulin can bind the brain endothelial cell to affect intracellular signaling. Therefore, we hypothesized CNS access to insulin could be affected by the combination of apoE isoform, sex, and diet. We analyzed insulin BBB pharmacokinetics in aged apoE targeted ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-05-31T22:37:16.458Z","creation":"2022-02-11T11:13:10.384Z"},"accession":"S-EPMC8452709","cross_references":{"pubmed":["34545146"],"doi":["10.1038/s41598-021-98061-1"]}}