biostudies-literatureKontopantelis ECancer Research UK100144https://www.ebi.ac.uk/biostudies/studies/S-EPMC8454637biostudies-literatureUnknown7<h4>Background</h4>Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess deaths have been directly related to COVID-19 infection. We investigated geographical and socioeconomic patterns in excess deaths for major groups of underlying causes during the pandemic.<h4>Methods</h4>Weekly mortality data from 27/12/2014 to 2/10/2020 for England and Wales were obtained from the Office of National Statistics. Negative binomial regressions were used to model death counts based on pre-pandemic trends for deaths caused directly by COVID-19 (and other respiratory causes) and those caused indirectly by it (cardiovascular disease or diabetes, cancers, and all other indirect The Lancet regional health. EuropeExcess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study.PMC845463728701Price GAshcroft DMVan Spall HGCAbel KMMamas MADoran TPierce MMorciano MRutter MKMartin GPFaivre-Finn CKontopantelis EGale CPGraham MMWebb RTCastro AfalseExcess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study.<h4>Background</h4>Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess deaths have been directly related to COVID-19 infection. We investigated geographical and socioeconomic patterns in excess deaths for major groups of underlying causes during the pandemic.<h4>Methods</h4>Weekly mortality data from 27/12/2014 to 2/10/2020 for England and Wales were obtained from the Office of National Statistics. Negative binomial regressions were used to model death counts based on pre-pandemic trends for deaths caused directly by COVID-19 (and other respiratory causes) and those caused indirectly by it (cardiovascular disease or diabetes, cancers, and all other indirect 2021-01-01T00:00:00Z2021 Aug2026-05-08T10:12:09.901Z2022-02-11T11:16:26.225ZS-EPMC84546373455784510.1016/j.lanepe.2021.100144