biostudies-literatureDenburg MRNIDDK NIH HHSNIDDK1178-1189https://www.ebi.ac.uk/biostudies/studies/S-EPMC8455058biostudies-literatureUnknown16(8)<h4>Background and objectives</h4>Metabolomics facilitates the discovery of biomarkers and potential therapeutic targets for CKD progression.<h4>Design, setting, participants, & measurements</h4>We evaluated an untargeted metabolomics quantification of stored plasma samples from 645 Chronic Kidney Disease in Children (CKiD) participants. Metabolites were standardized and logarithmically transformed. Cox proportional hazards regression examined the association between 825 nondrug metabolites and progression to the composite outcome of KRT or 50% reduction of eGFR, adjusting for age, sex, race, body mass index, hypertension, glomerular versus nonglomerular diagnosis, proteinuria, and baseline eGFR. Stratified analyses were performed within subgroups of glomerular/nonglomerular diagnosis and Clinical journal of the American Society of Nephrology : CJASNMetabolite Biomarkers of CKD Progression in Children.PMC8455058U01DK085689U01 DK106981U01DK103225U01DK106982U01 DK103225U01 DK106982U01 DK066174U01 DK085689U01 DK066143U24 DK066116K23 DK093556K23DK093556Abraham ACoca SSarnak MKimmel PLTin AShou HDubin RLevey ASFoster MXie DRebholz CMRovin BIx JFurth SShlipak MGVasan RSChen JGossett DWaikar SClish CHostetter TGutierrez OMSabbisetti VAbraham AGXu YInker LAWarady BGanz PRebholz CRhee EDeo RRamachandran VSBonventre JFeldman HIParikh CMifflin TSeegmiller JMcMahon GNadkarni GNGreenberg JRhee EPFurth SLCKD Biomarkers ConsortiumGrams MFerket BSAnderson AWhitehead KSchelling JGrams MEBallard SWarady BAMassaro JKlein JDenburg MCoresh JDenburg MRCollins HfalseMetabolite Biomarkers of CKD Progression in Children.<h4>Background and objectives</h4>Metabolomics facilitates the discovery of biomarkers and potential therapeutic targets for CKD progression.<h4>Design, setting, participants, & measurements</h4>We evaluated an untargeted metabolomics quantification of stored plasma samples from 645 Chronic Kidney Disease in Children (CKiD) participants. Metabolites were standardized and logarithmically transformed. Cox proportional hazards regression examined the association between 825 nondrug metabolites and progression to the composite outcome of KRT or 50% reduction of eGFR, adjusting for age, sex, race, body mass index, hypertension, glomerular versus nonglomerular diagnosis, proteinuria, and baseline eGFR. Stratified analyses were performed within subgroups of glomerular/nonglomerular diagnosis and 2021-01-01T00:00:00Z2021 Aug2025-04-26T16:30:25.818Z2025-04-06T15:12:11.018ZS-EPMC84550583436278510.2215/cjn.0022012110.2215/CJN.00220121