biostudies-literatureNye JANHLBI NIH HHS5072-5084https://www.ebi.ac.uk/biostudies/studies/S-EPMC8455441biostudies-literatureUnknown48(9)This work expands on the implementation of three-dimensional (3D) normalized gradient fields to correct for whole-body motion and cardiac creep in [N-13]-ammonia patient studies and evaluates its accuracy using a dynamic phantom simulation model.<h4>Methods</h4>A full rigid-body algorithm was developed using 3D normalized gradient fields including a multi-resolution step and sampling off the voxel grid to reduce interpolation artifacts. Optimization was performed using a weighted similarity metric that accounts for opposing gradients between images of blood pool and perfused tissue without the need for segmentation. Forty-three retrospective dynamic [N-13]-ammonia PET/CT rest/adenosine-stress patient studies were motion corrected and the mean motion parameters plotted at each frame time poMedical physicsDynamic cardiac PET motion correction using 3D normalized gradient fields in patients and phantom simulations.PMC8455441R01 HL143350Hwang DKoo BKDavid Cooke CBom HSGarcia EVPiccinelli MLee JMCho SGNye JAPaeng JCFolks RfalseDynamic cardiac PET motion correction using 3D normalized gradient fields in patients and phantom simulations.This work expands on the implementation of three-dimensional (3D) normalized gradient fields to correct for whole-body motion and cardiac creep in [N-13]-ammonia patient studies and evaluates its accuracy using a dynamic phantom simulation model.<h4>Methods</h4>A full rigid-body algorithm was developed using 3D normalized gradient fields including a multi-resolution step and sampling off the voxel grid to reduce interpolation artifacts. Optimization was performed using a weighted similarity metric that accounts for opposing gradients between images of blood pool and perfused tissue without the need for segmentation. Forty-three retrospective dynamic [N-13]-ammonia PET/CT rest/adenosine-stress patient studies were motion corrected and the mean motion parameters plotted at each frame time po2021-01-01T00:00:00Z2021 Sep2025-04-19T01:36:15.776Z2025-04-07T12:18:10.019ZS-EPMC84554413417409510.1002/mp.15059