biostudies-literatureUnknown13(5)Gutierrez-Falcon AIA strain of Alcaligenes faecalis A12C (A. faecalis A12C) isolated from Argyrosomus regius is a probiotic in fish. Previous experiments showed that A. faecalis A12C had inhibitory effects on the growth of multidrug-resistant bacteria. We aimed to confirm whether A. faecalis A12C is safe and has adequate intestinal colonization in experimental rats, and evaluate its efficacy in an animal model of peritonitis. We used 30 male rats, randomly divided into 6 groups (n = 5): three groups (HA7, HA15, HA30) received A. faecalis A12C in drinking water (6 × 10⁸ CFU/mL) for 7 days, and three control groups received drinking water only. All groups were evaluated at 7, 15, and 30 days. Survival after A. faecalis A12C administration was 100% in all groups. Mild eosinophilia (1.5%, p < 0.01) anProbiotics and antimicrobial proteins1326-1337https://www.ebi.ac.uk/biostudies/studies/S-EPMC8463381biostudies-literatureProbiotic Properties of Alcaligenes faecalis Isolated from Argyrosomus regius in Experimental Peritonitis (Rat Model).PMC8463381Benitez ABRamos-Nuez AMGutierrez-Falcon AICastillo DFPReal Valcarcel FCampelo FAMartin-Barrasa JLChamizo-Lopez FJGonzalez-Martin JMRivero-Vera JCVillar Jde Los Monteros Y Zayas AEGarcia-Laorden MICabrera CDSalgueiro PNFrias-Beneyto RCaballero JMfalseProbiotic Properties of Alcaligenes faecalis Isolated from Argyrosomus regius in Experimental Peritonitis (Rat Model).A strain of Alcaligenes faecalis A12C (A. faecalis A12C) isolated from Argyrosomus regius is a probiotic in fish. Previous experiments showed that A. faecalis A12C had inhibitory effects on the growth of multidrug-resistant bacteria. We aimed to confirm whether A. faecalis A12C is safe and has adequate intestinal colonization in experimental rats, and evaluate its efficacy in an animal model of peritonitis. We used 30 male rats, randomly divided into 6 groups (n = 5): three groups (HA7, HA15, HA30) received A. faecalis A12C in drinking water (6 × 10⁸ CFU/mL) for 7 days, and three control groups received drinking water only. All groups were evaluated at 7, 15, and 30 days. Survival after A. faecalis A12C administration was 100% in all groups. Mild eosinophilia (1.5%, p < 0.01) an2021-01-01T00:00:00Z2021 Oct2025-04-19T21:38:10.576Z2022-02-11T11:56:23.532ZS-EPMC84633813371330910.1007/s12602-021-09767-7