{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barranco N"],"funding":["Generalitat de Catalunya","Instituto de Salud Carlos III","Ministerio de Economía y Competitividad"],"pagination":["37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8466657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising cerebrospinal fluid (CSF) indicators of synaptic failure in AD patients. However, their value as biomarkers has not yet been determined.<h4>Methods</h4>Immunoassays were performed to analyze the secretory proteins prohormone convertases PC1/3 and PC2, carboxypeptidase E (CPE), secretogranins SgIII and SgII, and Cystatin C in the cerebral cortex (n = 45, provided by Bellvitge University Hospital) and CSF samples (n = 66, provided by The Sant Pau Initiative on Neurodegeneration cohort) from AD patients (n = 56) and age-matched controls (n = 55).<h4>Results</h4>In A"],"journal":["Translational neurodegeneration"],"pubmed_title":["Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease."],"pmcid":["PMC8466657"],"funding_grant_id":["PI14/1561","PI17/01896","SLT006/17/125","2014SGR-0235","PID2019-107738RB-I00","2017SGR1255","PI18/00435","BFU2016-80868-R"],"pubmed_authors":["Sanchez-Dominguez I","Pla V","Ferrer I","Alcolea D","Aguado F","Barranco N","Lleo A","Fischer-Colbrie R"],"additional_accession":[]},"is_claimable":false,"name":"Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease.","description":"<h4>Background</h4>New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising cerebrospinal fluid (CSF) indicators of synaptic failure in AD patients. However, their value as biomarkers has not yet been determined.<h4>Methods</h4>Immunoassays were performed to analyze the secretory proteins prohormone convertases PC1/3 and PC2, carboxypeptidase E (CPE), secretogranins SgIII and SgII, and Cystatin C in the cerebral cortex (n = 45, provided by Bellvitge University Hospital) and CSF samples (n = 66, provided by The Sant Pau Initiative on Neurodegeneration cohort) from AD patients (n = 56) and age-matched controls (n = 55).<h4>Results</h4>In A","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-08T09:05:06.681Z","creation":"2022-02-11T14:17:53.72Z"},"accession":"S-EPMC8466657","cross_references":{"pubmed":["34565482"],"doi":["10.1186/s40035-021-00263-0"]}}