{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Maklad A"],"pubmed_abstract":["Dysregulation in calcium signalling is implicated in several cancer-associated processes, including cell proliferation, migration, invasion and therapy resistance. Modulators of specific calcium-regulating proteins have been proposed as promising future therapeutic agents for some cancers. Alterations in calcium signalling have been extensively studied in some cancers; however, this area of research is highly underexplored in medulloblastoma (MB), the most common paediatric malignant brain tumour. Current MB treatment modalities are not completely effective and can result in several long-lasting mental complications. Hence, new treatment strategies are needed. In this study, we sought to probe the landscape of calcium signalling regulators to uncover those most likely to be involved in MB "],"journal":["Genes"],"pagination":["1329"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8468187"],"repository":["biostudies-literature"],"pubmed_title":["Calcium Signalling in Medulloblastoma: An In Silico Analysis of the Expression of Calcium Regulating Genes in Patient Samples."],"pmcid":["PMC8468187"],"pubmed_authors":["Maklad A","Sedeeq M","Azimi I","Milevskiy MJG"],"additional_accession":[]},"is_claimable":false,"name":"Calcium Signalling in Medulloblastoma: An In Silico Analysis of the Expression of Calcium Regulating Genes in Patient Samples.","description":"Dysregulation in calcium signalling is implicated in several cancer-associated processes, including cell proliferation, migration, invasion and therapy resistance. Modulators of specific calcium-regulating proteins have been proposed as promising future therapeutic agents for some cancers. Alterations in calcium signalling have been extensively studied in some cancers; however, this area of research is highly underexplored in medulloblastoma (MB), the most common paediatric malignant brain tumour. Current MB treatment modalities are not completely effective and can result in several long-lasting mental complications. Hence, new treatment strategies are needed. In this study, we sought to probe the landscape of calcium signalling regulators to uncover those most likely to be involved in MB ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-04-07T16:14:01.246Z","creation":"2022-02-11T11:41:15.66Z"},"accession":"S-EPMC8468187","cross_references":{"pubmed":["34573310"],"doi":["10.3390/genes12091329"]}}