{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(18)"],"submitter":["Randrianarivo S"],"pubmed_abstract":["Chemical and biological investigation of the Madagascar endemic plant <i>Saldinia proboscidea</i> led to the isolation of an isomer of artemisinin, (-)-6-epi-artemisinin (<b>2</b>). Its structure was elucidated using a combination of NMR and mass spectrometry. The absolute configuration was established by chemical syntheses of compound <b>2</b> as well as a new stereoisomer (<b>3</b>). The comparable bioactivities of artemisinin (<b>1</b>) and its isomer (-)-6-epi-artemisinin (<b>2</b>) revealed that this change in configuration was not critical to their biological properties. Bioactivity was assessed using an apoptosis induction assay, a SARS-CoV-2 inhibitor assay, and a haematin polymerization inhibitory activity (HPIA) assay. This is the first report of an artemisinin-related compound f"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["5540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8472513"],"repository":["biostudies-literature"],"pubmed_title":["(-)-6-epi-Artemisinin, a Natural Stereoisomer of (+)-Artemisinin in the Opposite Enantiomeric Series, from the Endemic Madagascar Plant <i>Saldinia proboscidea</i>, an Atypical Source."],"pmcid":["PMC8472513"],"pubmed_authors":["Rafanomezantsoa S","Randrianarivo S","Randriamampionona H","Haramaty L","Rasolohery C","Rafanomezantsoa RM","Andrianasolo EH"],"additional_accession":[]},"is_claimable":false,"name":"(-)-6-epi-Artemisinin, a Natural Stereoisomer of (+)-Artemisinin in the Opposite Enantiomeric Series, from the Endemic Madagascar Plant <i>Saldinia proboscidea</i>, an Atypical Source.","description":"Chemical and biological investigation of the Madagascar endemic plant <i>Saldinia proboscidea</i> led to the isolation of an isomer of artemisinin, (-)-6-epi-artemisinin (<b>2</b>). Its structure was elucidated using a combination of NMR and mass spectrometry. The absolute configuration was established by chemical syntheses of compound <b>2</b> as well as a new stereoisomer (<b>3</b>). The comparable bioactivities of artemisinin (<b>1</b>) and its isomer (-)-6-epi-artemisinin (<b>2</b>) revealed that this change in configuration was not critical to their biological properties. Bioactivity was assessed using an apoptosis induction assay, a SARS-CoV-2 inhibitor assay, and a haematin polymerization inhibitory activity (HPIA) assay. This is the first report of an artemisinin-related compound f","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-02T03:12:32.447Z","creation":"2022-02-11T11:37:17.473Z"},"accession":"S-EPMC8472513","cross_references":{"pubmed":["34577011"],"doi":["10.3390/molecules26185540"]}}