{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Sakanaka A"],"pubmed_abstract":["Periodontitis is an inflammatory disorder caused by disintegration of the balance between the periodontal microbiome and host response. While growing evidence suggests links between periodontitis and various metabolic disorders including type 2 diabetes (T2D), non-alcoholic liver disease, and cardiovascular disease (CVD), which often coexist in individuals with abdominal obesity, factors linking periodontal inflammation to common metabolic alterations remain to be fully elucidated. More detailed characterization of metabolomic profiles associated with multiple oral and cardiometabolic traits may provide better understanding of the complexity of oral-systemic crosstalk and its underlying mechanism. We performed comprehensive profiling of plasma and salivary metabolomes using untargeted gas "],"journal":["Frontiers in molecular biosciences"],"pagination":["742002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8473679"],"repository":["biostudies-literature"],"pubmed_title":["Saliva and Plasma Reflect Metabolism Altered by Diabetes and Periodontitis."],"pmcid":["PMC8473679"],"pubmed_authors":["Nishizawa H","Taya N","Amano A","Mayumi S","Kuboniwa M","Omori K","Ishikawa A","Shimomura I","Fukusaki E","Katakami N","Sakanaka A","Furuno M","Tanaka Isomura E"],"additional_accession":[]},"is_claimable":false,"name":"Saliva and Plasma Reflect Metabolism Altered by Diabetes and Periodontitis.","description":"Periodontitis is an inflammatory disorder caused by disintegration of the balance between the periodontal microbiome and host response. While growing evidence suggests links between periodontitis and various metabolic disorders including type 2 diabetes (T2D), non-alcoholic liver disease, and cardiovascular disease (CVD), which often coexist in individuals with abdominal obesity, factors linking periodontal inflammation to common metabolic alterations remain to be fully elucidated. More detailed characterization of metabolomic profiles associated with multiple oral and cardiometabolic traits may provide better understanding of the complexity of oral-systemic crosstalk and its underlying mechanism. We performed comprehensive profiling of plasma and salivary metabolomes using untargeted gas ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-27T21:55:18.846Z","creation":"2022-02-11T11:30:17.722Z"},"accession":"S-EPMC8473679","cross_references":{"pubmed":["34589520"],"doi":["10.3389/fmolb.2021.742002"]}}