{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grover A"],"funding":["Intramural NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["e4163-e4178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8475236"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["106(10)"],"pubmed_abstract":["<h4>Context</h4>Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.<h4>Objective</h4>To determine the effects of metreleptin on EE in patients with lipodystrophy.<h4>Design, setting, and patients</h4>Nonrandomized crossover study of 25 patients with lipodystrophy (National Institutes of Health, 2013-2018).<h4>Intervention</h4>The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metreleptin. The withdrawal cohort consisted of 8 previously metreleptin-treated patients, studied before and after 14 days of metreleptin withdrawal.<h4>Main outcom"],"journal":["The Journal of clinical endocrinology and metabolism"],"pubmed_title":["Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy."],"pmcid":["PMC8475236"],"funding_grant_id":["R01 DK071013","ZIA DK071013","DK075084-08","ZIA DK075084"],"pubmed_authors":["Quaye E","Christensen J","Grover A","Meehan CA","Valencia A","Marshall B","Brychta RJ","Chen KY","Startzell MS","Brown RJ"],"additional_accession":[]},"is_claimable":false,"name":"Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy.","description":"<h4>Context</h4>Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.<h4>Objective</h4>To determine the effects of metreleptin on EE in patients with lipodystrophy.<h4>Design, setting, and patients</h4>Nonrandomized crossover study of 25 patients with lipodystrophy (National Institutes of Health, 2013-2018).<h4>Intervention</h4>The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metreleptin. The withdrawal cohort consisted of 8 previously metreleptin-treated patients, studied before and after 14 days of metreleptin withdrawal.<h4>Main outcom","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T22:33:44.903Z","creation":"2025-02-19T03:24:12.978Z"},"accession":"S-EPMC8475236","cross_references":{"pubmed":["33890058"],"doi":["10.1210/clinem/dgab269"]}}