biostudies-literatureGrover AIntramural NIH HHSNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseasese4163-e4178https://www.ebi.ac.uk/biostudies/studies/S-EPMC8475236biostudies-literatureUnknown106(10)<h4>Context</h4>Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.<h4>Objective</h4>To determine the effects of metreleptin on EE in patients with lipodystrophy.<h4>Design, setting, and patients</h4>Nonrandomized crossover study of 25 patients with lipodystrophy (National Institutes of Health, 2013-2018).<h4>Intervention</h4>The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metreleptin. The withdrawal cohort consisted of 8 previously metreleptin-treated patients, studied before and after 14 days of metreleptin withdrawal.<h4>Main outcomThe Journal of clinical endocrinology and metabolismLeptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy.PMC8475236R01 DK071013ZIA DK071013DK075084-08ZIA DK075084Quaye EChristensen JGrover AMeehan CAValencia AMarshall BBrychta RJChen KYStartzell MSBrown RJfalseLeptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy.<h4>Context</h4>Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.<h4>Objective</h4>To determine the effects of metreleptin on EE in patients with lipodystrophy.<h4>Design, setting, and patients</h4>Nonrandomized crossover study of 25 patients with lipodystrophy (National Institutes of Health, 2013-2018).<h4>Intervention</h4>The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metreleptin. The withdrawal cohort consisted of 8 previously metreleptin-treated patients, studied before and after 14 days of metreleptin withdrawal.<h4>Main outcom2021-01-01T00:00:00Z2021 Sep2025-04-04T22:33:44.903Z2025-02-19T03:24:12.978ZS-EPMC84752363389005810.1210/clinem/dgab269