{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Huang F"],"pubmed_abstract":["We previously reported that enriched ubiquitinated proteins (UPs) from tumor cells have the potential to be used as immunotherapy vaccine against cancer. Here we enriched UPs from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line (4T1/EPB) and tested the efficacy of α-Al<sub>2</sub>O<sub>3</sub>-UPs-4T1/EPB (short for UPs-4T1/EPB) as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer. Vaccination with UPs-4T1/EPB exerted profound anti-tumor effects through augmented specific CD8<sup>+</sup> T cell responses and amplified T cell receptor diversity of tumor-infiltrating lymphocytes (TILs). Importantly, the combination with STING agonist further facil"],"journal":["Frontiers in immunology"],"pagination":["707298"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8475273"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer."],"pmcid":["PMC8475273"],"pubmed_authors":["Huang F","Wen Z","Aldarouish M","Chen Y","Wang X","Sun X","Wei Y","Zhao J","Pan N","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer.","description":"We previously reported that enriched ubiquitinated proteins (UPs) from tumor cells have the potential to be used as immunotherapy vaccine against cancer. Here we enriched UPs from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line (4T1/EPB) and tested the efficacy of α-Al<sub>2</sub>O<sub>3</sub>-UPs-4T1/EPB (short for UPs-4T1/EPB) as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer. Vaccination with UPs-4T1/EPB exerted profound anti-tumor effects through augmented specific CD8<sup>+</sup> T cell responses and amplified T cell receptor diversity of tumor-infiltrating lymphocytes (TILs). Importantly, the combination with STING agonist further facil","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-07T20:22:08.084Z","creation":"2022-02-11T11:43:44.64Z"},"accession":"S-EPMC8475273","cross_references":{"pubmed":["34589084"],"doi":["10.3389/fimmu.2021.707298"]}}