{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leyrer-Jackson JM"],"funding":["NIAAA NIH HHS","National Institutes of Health"],"pagination":["108674"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8475285"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["195"],"pubmed_abstract":["<h4>Background</h4>Alcohol abuse is a worldwide public health concern and leads to an estimated 90,000 alcohol-related deaths in the United States annually. Alcohol may promote its euphoric and motivational effects, in part, by activating the endogenous opioid system. Pro-opiomelanocortin (POMC) producing neurons located within the arcuate nucleus (ArcN) of the hypothalamus make up one circuit of the endogenous opioid system, and heavily projects to reward-related brain areas such as the amygdala, nucleus accumbens (NAc) and ventral tegmental area (VTA). POMC producing neurons release β-endorphin and other peptides that target opioid receptors within reward areas to elicit their associated rewarding effects. Here we explore ArcN POMC neuronal activation, as assessed via FosB expression, fo"],"journal":["Neuropharmacology"],"pubmed_title":["Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala."],"pmcid":["PMC8475285"],"funding_grant_id":["F32 AA027962","F32AA027962-01","R01 AA025590","R01AA025590"],"pubmed_authors":["Leyrer-Jackson JM","Hood LE","Olive MF"],"additional_accession":[]},"is_claimable":false,"name":"Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala.","description":"<h4>Background</h4>Alcohol abuse is a worldwide public health concern and leads to an estimated 90,000 alcohol-related deaths in the United States annually. Alcohol may promote its euphoric and motivational effects, in part, by activating the endogenous opioid system. Pro-opiomelanocortin (POMC) producing neurons located within the arcuate nucleus (ArcN) of the hypothalamus make up one circuit of the endogenous opioid system, and heavily projects to reward-related brain areas such as the amygdala, nucleus accumbens (NAc) and ventral tegmental area (VTA). POMC producing neurons release β-endorphin and other peptides that target opioid receptors within reward areas to elicit their associated rewarding effects. Here we explore ArcN POMC neuronal activation, as assessed via FosB expression, fo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-19T05:57:07.805Z","creation":"2025-04-19T05:57:07.805Z"},"accession":"S-EPMC8475285","cross_references":{"pubmed":["34153315"],"doi":["10.1016/j.neuropharm.2021.108674"]}}