{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(2)"],"submitter":["Terziroli Beretta-Piccoli B"],"pubmed_abstract":["Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti-nuclear and/or anti-smooth muscle antibodies, while type 2 AIH, affecting mostly children, is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 antibody. While the autoantigens of type 2 AIH are well defined, being the cytochrome P4502D6 (CYP2D6) and the formiminotransferase cyclodeaminase (FTCD), in type 1 AIH they remain to be identified. AIH-1 predisposition is conferred by possession of the"],"journal":["Cellular & molecular immunology"],"pagination":["158-176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8475398"],"repository":["biostudies-literature"],"pubmed_title":["Autoimmmune hepatitis."],"pmcid":["PMC8475398"],"pubmed_authors":["Mieli-Vergani G","Vergani D","Terziroli Beretta-Piccoli B"],"additional_accession":[]},"is_claimable":false,"name":"Autoimmmune hepatitis.","description":"Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti-nuclear and/or anti-smooth muscle antibodies, while type 2 AIH, affecting mostly children, is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 antibody. While the autoantigens of type 2 AIH are well defined, being the cytochrome P4502D6 (CYP2D6) and the formiminotransferase cyclodeaminase (FTCD), in type 1 AIH they remain to be identified. AIH-1 predisposition is conferred by possession of the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-22T10:14:46.742Z","creation":"2022-02-11T14:23:15.943Z"},"accession":"S-EPMC8475398","cross_references":{"pubmed":["34580437"],"doi":["10.1038/s41423-021-00768-8"]}}