{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim SH"],"funding":["University of California San Diego","Alexander Saint-Amand Fellowship","Alzheimer’s Association","Tau Consortium","NIA NIH HHS","Emory University","NINDS NIH HHS","University of Pittsburg","National Institutes of Health","NIH HHS","University of California Irvine"],"pagination":["835-843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8476083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80(9)"],"pubmed_abstract":["Patients with essential tremor (ET) frequently develop concurrent dementia, which is often assumed to represent co-morbid Alzheimer disease (AD). Autopsy studies have identified a spectrum of tau pathologies in ET and tau isoforms have not been examined in ET. We performed immunoblotting using autopsy cerebral cortical tissue from patients with ET (n = 13), progressive supranuclear palsy ([PSP], n = 10), Pick disease ([PiD], n = 2), and AD (n = 7). Total tau in ET samples was similar to that in PSP and PiD but was significantly lower than that in AD. Abnormal tau levels measured using the AT8 phospho-tau specific (S202/T205/S208) monoclonal antibody in ET were similar to those in PSP but were lower than in PiD and AD. In aggregates, tau with 3 microtubule-binding domain repeats (3R) was si"],"journal":["Journal of neuropathology and experimental neurology"],"pubmed_title":["Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies."],"pmcid":["PMC8476083"],"funding_grant_id":["R01AG054008","P30 AG066462","F32AG056098","R01NS086736","P50 AG025688","NIRG-15-363188","P50 AG005131","P30 NS055077","P50 AG005133","P50 AG016573","P30 AG062429","R01NS095252"],"pubmed_authors":["Kim SH","Louis ED","Cortes EP","Vonsattel JG","Bennet DA","Crary JF","Cosentino S","Farrell K","Faust PL"],"additional_accession":[]},"is_claimable":false,"name":"Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.","description":"Patients with essential tremor (ET) frequently develop concurrent dementia, which is often assumed to represent co-morbid Alzheimer disease (AD). Autopsy studies have identified a spectrum of tau pathologies in ET and tau isoforms have not been examined in ET. We performed immunoblotting using autopsy cerebral cortical tissue from patients with ET (n = 13), progressive supranuclear palsy ([PSP], n = 10), Pick disease ([PiD], n = 2), and AD (n = 7). Total tau in ET samples was similar to that in PSP and PiD but was significantly lower than that in AD. Abnormal tau levels measured using the AT8 phospho-tau specific (S202/T205/S208) monoclonal antibody in ET were similar to those in PSP but were lower than in PiD and AD. In aggregates, tau with 3 microtubule-binding domain repeats (3R) was si","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T22:32:50.463Z","creation":"2025-02-19T03:23:51.753Z"},"accession":"S-EPMC8476083","cross_references":{"pubmed":["34363663"],"doi":["10.1093/jnen/nlab073"]}}