{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan BE"],"funding":["national healthcare group"],"pagination":["646-662"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8476716"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(3)"],"pubmed_abstract":["Severe COVID-19 patients demonstrate hypercoagulability, necessitating thromboprophylaxis. However, less is known about the haemostatic profile in mild COVID-19 patients. We performed an age and gender-matched prospective study of 10 severe and 10 mild COVID-19 patients. Comprehensive coagulation profiling together with Thromboelastography and Clot Waveform Analysis were performed. FBC, PT, APTT, D-dimer, fibrinogen and CWA were repeated every 3 days for both groups and repeat TEG was performed for severe patients up till 15 days. On recruitment, severe patients had markers reflecting hypercoagulability including raised median D-dimer 1.0 μg/mL (IQR 0.6, 1.4) (p = 0.0004), fibrinogen 5.6 g/L (IQR 4.9, 6.6) (p = 0.002), Factor VIII 206% (IQR 171, 203) and vWF levels 265.5% (IQR 206, 321). M"],"journal":["Journal of thrombosis and thrombolysis"],"pubmed_title":["Global haemostatic tests demonstrate the absence of parameters of hypercoagulability in non-hypoxic mild COVID-19 patients: a prospective matched study."],"pmcid":["PMC8476716"],"funding_grant_id":["COVID19 CG0004"],"pubmed_authors":["Lye DC","Lee RM","Lau SL","Lim SP","Bok CF","Young BE","Tan HT","Fan BE","Ang MK","Chia YW","Kuperan P","Chan SSW","Sum CLL","Christopher D","Lim JY","Wong SW","Ong KH","Ramanathan K","Lim GH"],"additional_accession":[]},"is_claimable":false,"name":"Global haemostatic tests demonstrate the absence of parameters of hypercoagulability in non-hypoxic mild COVID-19 patients: a prospective matched study.","description":"Severe COVID-19 patients demonstrate hypercoagulability, necessitating thromboprophylaxis. However, less is known about the haemostatic profile in mild COVID-19 patients. We performed an age and gender-matched prospective study of 10 severe and 10 mild COVID-19 patients. Comprehensive coagulation profiling together with Thromboelastography and Clot Waveform Analysis were performed. FBC, PT, APTT, D-dimer, fibrinogen and CWA were repeated every 3 days for both groups and repeat TEG was performed for severe patients up till 15 days. On recruitment, severe patients had markers reflecting hypercoagulability including raised median D-dimer 1.0 μg/mL (IQR 0.6, 1.4) (p = 0.0004), fibrinogen 5.6 g/L (IQR 4.9, 6.6) (p = 0.002), Factor VIII 206% (IQR 171, 203) and vWF levels 265.5% (IQR 206, 321). M","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-21T16:26:42.397Z","creation":"2022-02-11T11:25:35.839Z"},"accession":"S-EPMC8476716","cross_references":{"pubmed":["34581945"],"doi":["10.1007/s11239-021-02575-4"]}}