{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chow MR"],"funding":["NIDCD NIH HHS"],"pagination":["521-532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8477665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["384(6)"],"pubmed_abstract":["<h4>Background</h4>Bilateral vestibular hypofunction is associated with chronic disequilibrium, postural instability, and unsteady gait owing to failure of vestibular reflexes that stabilize the eyes, head, and body. A vestibular implant may be effective in alleviating symptoms.<h4>Methods</h4>Persons who had had ototoxic (7 participants) or idiopathic (1 participant) bilateral vestibular hypofunction for 2 to 23 years underwent unilateral implantation of a prosthesis that electrically stimulates the three semicircular canal branches of the vestibular nerve. Clinical outcomes included the score on the Bruininks-Oseretsky Test of Motor Proficiency balance subtest (range, 0 to 36, with higher scores indicating better balance), time to failure on the modified Romberg test (range, 0 to 30 seco"],"journal":["The New England journal of medicine"],"pubmed_title":["Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant."],"pmcid":["PMC8477665"],"funding_grant_id":["T32 DC000023","R01 DC013536","K23 DC018302"],"pubmed_authors":["Trevino Guajardo C","Valentin NS","Boutros PJ","Sun DQ","Carey JP","Schoo DP","Bowditch SP","Gimmon Y","Schubert MC","Lane KE","Ayiotis AI","Chow MR","Ward BK","Rahman MA","Morris BJ","Della Santina CC"],"additional_accession":[]},"is_claimable":false,"name":"Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant.","description":"<h4>Background</h4>Bilateral vestibular hypofunction is associated with chronic disequilibrium, postural instability, and unsteady gait owing to failure of vestibular reflexes that stabilize the eyes, head, and body. A vestibular implant may be effective in alleviating symptoms.<h4>Methods</h4>Persons who had had ototoxic (7 participants) or idiopathic (1 participant) bilateral vestibular hypofunction for 2 to 23 years underwent unilateral implantation of a prosthesis that electrically stimulates the three semicircular canal branches of the vestibular nerve. Clinical outcomes included the score on the Bruininks-Oseretsky Test of Motor Proficiency balance subtest (range, 0 to 36, with higher scores indicating better balance), time to failure on the modified Romberg test (range, 0 to 30 seco","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-08T07:02:21.368Z","creation":"2025-04-03T22:48:06.399Z"},"accession":"S-EPMC8477665","cross_references":{"pubmed":["33567192"],"doi":["10.1056/NEJMoa2020457","10.1056/nejmoa2020457"]}}