{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Li W"],"pubmed_abstract":["<h4>Background</h4>MiR-10a-3p is associated with the pathogenesis of many immune inflammatory diseases including <i>Mycoplasma pneumoniae</i> pneumonia (MPP), and cytochrome coxidase assembly homologue 11 (COX11) is one of its direct target proteins. This study investigates the function and mechanism of miR-10a-3p targeting with <i>COX11</i> in the development and progression of paediatric MPP.<h4>Methods</h4>Ninty-seven paediatric MPP patients and 100 age- and sex-matched healthy children were enrolled. Clinical and laboratory indicators of paediatric MPP patients were collected. The mRNA levels of the <i>COX11</i> gene and miR-10a-3p were detected by qRT-PCR. THP-1 mononuclear macrophages were stimulated using MPP lipid-associated membrane proteins (Mp-LAMPs). The relative expression lev"],"journal":["Journal of thoracic disease"],"pagination":["5409-5418"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8482332"],"repository":["biostudies-literature"],"pubmed_title":["The role of targeted regulation of <i>COX11</i> by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia."],"pmcid":["PMC8482332"],"pubmed_authors":["Li W","Ding X","Tan M","Li C","Zhao R","Xie Z","Xiong D","Yang C","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"The role of targeted regulation of <i>COX11</i> by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia.","description":"<h4>Background</h4>MiR-10a-3p is associated with the pathogenesis of many immune inflammatory diseases including <i>Mycoplasma pneumoniae</i> pneumonia (MPP), and cytochrome coxidase assembly homologue 11 (COX11) is one of its direct target proteins. This study investigates the function and mechanism of miR-10a-3p targeting with <i>COX11</i> in the development and progression of paediatric MPP.<h4>Methods</h4>Ninty-seven paediatric MPP patients and 100 age- and sex-matched healthy children were enrolled. Clinical and laboratory indicators of paediatric MPP patients were collected. The mRNA levels of the <i>COX11</i> gene and miR-10a-3p were detected by qRT-PCR. THP-1 mononuclear macrophages were stimulated using MPP lipid-associated membrane proteins (Mp-LAMPs). The relative expression lev","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-05T14:05:28.122Z","creation":"2024-11-07T08:10:14.25Z"},"accession":"S-EPMC8482332","cross_references":{"pubmed":["34659807"],"doi":["10.21037/jtd-21-710"]}}