biostudies-literatureUnknown13(9)Li W<h4>Background</h4>MiR-10a-3p is associated with the pathogenesis of many immune inflammatory diseases including <i>Mycoplasma pneumoniae</i> pneumonia (MPP), and cytochrome coxidase assembly homologue 11 (COX11) is one of its direct target proteins. This study investigates the function and mechanism of miR-10a-3p targeting with <i>COX11</i> in the development and progression of paediatric MPP.<h4>Methods</h4>Ninty-seven paediatric MPP patients and 100 age- and sex-matched healthy children were enrolled. Clinical and laboratory indicators of paediatric MPP patients were collected. The mRNA levels of the <i>COX11</i> gene and miR-10a-3p were detected by qRT-PCR. THP-1 mononuclear macrophages were stimulated using MPP lipid-associated membrane proteins (Mp-LAMPs). The relative expression levJournal of thoracic disease5409-5418https://www.ebi.ac.uk/biostudies/studies/S-EPMC8482332biostudies-literatureThe role of targeted regulation of <i>COX11</i> by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia.PMC8482332Li WDing XTan MLi CZhao RXie ZXiong DYang CXu JfalseThe role of targeted regulation of <i>COX11</i> by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia.<h4>Background</h4>MiR-10a-3p is associated with the pathogenesis of many immune inflammatory diseases including <i>Mycoplasma pneumoniae</i> pneumonia (MPP), and cytochrome coxidase assembly homologue 11 (COX11) is one of its direct target proteins. This study investigates the function and mechanism of miR-10a-3p targeting with <i>COX11</i> in the development and progression of paediatric MPP.<h4>Methods</h4>Ninty-seven paediatric MPP patients and 100 age- and sex-matched healthy children were enrolled. Clinical and laboratory indicators of paediatric MPP patients were collected. The mRNA levels of the <i>COX11</i> gene and miR-10a-3p were detected by qRT-PCR. THP-1 mononuclear macrophages were stimulated using MPP lipid-associated membrane proteins (Mp-LAMPs). The relative expression lev2021-01-01T00:00:00Z2021 Sep2025-04-05T14:05:28.122Z2024-11-07T08:10:14.25ZS-EPMC84823323465980710.21037/jtd-21-710