biostudies-literatureKahr PCNICHD NIH HHSNIDCR NIH HHSAmerican Heart Association-American Stroke AssociationNHLBI NIH HHS163-172https://www.ebi.ac.uk/biostudies/studies/S-EPMC8482537biostudies-literatureUnknown478The cardiac conduction system is a network of heterogeneous cell population that initiates and propagates electric excitations in the myocardium. Purkinje fibers, a network of specialized myocardial cells, comprise the distal end of the conduction system in the ventricles. The developmental origins of Purkinje fibers and their roles during cardiac physiology and arrhythmia have been reported. However, it is not clear if they play a role during ischemic injury and heart regeneration. Here we introduce a novel tamoxifen-inducible Cre allele that specifically labels a broad range of components in the cardiac conduction system while excludes other cardiac cell types and vital organs. Using this new allele, we investigated the cellular and molecular response of Purkinje fibers to myocardial injDevelopmental biologyA novel transgenic Cre allele to label mouse cardiac conduction system.PMC8482537R01 HL118761P50 HD10355516POST2643012217SDG33400141U54 HD083092R01 DE023177Kahr PCTao GHill MCLi SZhang MMartin JFKadow ZAfalseA novel transgenic Cre allele to label mouse cardiac conduction system.The cardiac conduction system is a network of heterogeneous cell population that initiates and propagates electric excitations in the myocardium. Purkinje fibers, a network of specialized myocardial cells, comprise the distal end of the conduction system in the ventricles. The developmental origins of Purkinje fibers and their roles during cardiac physiology and arrhythmia have been reported. However, it is not clear if they play a role during ischemic injury and heart regeneration. Here we introduce a novel tamoxifen-inducible Cre allele that specifically labels a broad range of components in the cardiac conduction system while excludes other cardiac cell types and vital organs. Using this new allele, we investigated the cellular and molecular response of Purkinje fibers to myocardial inj2021-01-01T00:00:00Z2021 Oct2026-04-08T18:22:07.032Z2025-04-05T20:45:03.361ZS-EPMC84825373424572510.1016/j.ydbio.2021.07.005