{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Wang G"],"pubmed_abstract":["In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario, suppressing the secretion of tumor-derived exosomes may aid therapy. Here, we develop an assembly of exosome inhibitor (GW4869) and ferroptosis inducer (Fe<sup>3+</sup>) via amphiphilic hyaluronic acid. Cooperation between the two active components in the constructed nanounit induces an anti-tumor immunoresponse to B16F10 melanoma cells and stimulates cytotoxic T lymphocytes and immunological memory. The nanounit enhances the response to PD-L1 checkpoint blockade and may represent a therapeuti"],"journal":["Nature communications"],"pagination":["5733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8484261"],"repository":["biostudies-literature"],"pubmed_title":["A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis."],"pmcid":["PMC8484261"],"pubmed_authors":["Li W","Sang W","Yan J","Li J","Zhang Z","Tian H","Tian Y","Xie L","Wang G","Li B","Dai Y"],"additional_accession":[]},"is_claimable":false,"name":"A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.","description":"In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario, suppressing the secretion of tumor-derived exosomes may aid therapy. Here, we develop an assembly of exosome inhibitor (GW4869) and ferroptosis inducer (Fe<sup>3+</sup>) via amphiphilic hyaluronic acid. Cooperation between the two active components in the constructed nanounit induces an anti-tumor immunoresponse to B16F10 melanoma cells and stimulates cytotoxic T lymphocytes and immunological memory. The nanounit enhances the response to PD-L1 checkpoint blockade and may represent a therapeuti","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-21T17:34:58.053Z","creation":"2025-04-21T17:34:58.053Z"},"accession":"S-EPMC8484261","cross_references":{"pubmed":["34593794"],"doi":["10.1038/s41467-021-25990-w"]}}