{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harrewijn A"],"funding":["Intramural NIH HHS","NICHD NIH HHS","NIBIB NIH HHS","NIDA NIH HHS","NIA NIH HHS","NIMH NIH HHS","Dutch Research Council (NWO)","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","CSRD VA"],"pagination":["502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8486763"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5-90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ,"],"journal":["Translational psychiatry"],"pubmed_title":["Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group."],"pmcid":["PMC8486763"],"funding_grant_id":["R01 MH117601","019.201SG.022","K23 MH114023","U01 DA041117","U24 DA041123","U54 EB020403","K99 MH117274","K23 MH 086686","U24 DA041147","K23 MH100259","K23 MH086686","R01 MH108509","R01 MH101497","U01 DA041174","ZIA MH002798","K23 MH109983","R01 MH065413","U01 DA041134","R56 AG058854","U01 DA041156","K23MH114023","U01 DA041093","K99MH117274","K23MH100259","T32 MH014654","U01 DA041106","U01 DA041028","R01 MH116147","U01 DA041089","U01 DA041022","R01 MH101486","I01 CX000994","U01 DA041120","K23MH109983","U01 DA041148","K24 MH064122","U01 DA041048","R01 MH 108509","U01 DA041025","ZIA MH002782","R01MH11760","K99 HD105002","T32 MH100019","R01MH101497"],"pubmed_authors":["Wu MJ","Larsen B","Volzke H","Soares JC","Cardinale EM","Groenewold NA","Filippi M","Benson B","Pan PM","Hammoud MZ","Meeten F","Smoller JW","Aghajani M","Winkler AM","Gosnell S","Alberton BAV","Van der Wee NJA","Filippi CA","Grabe HJ","Van der Auwera S","Makovac E","Ball TM","Grillon C","Brambilla P","Paulus MP","Diefenbach GJ","Fonzo GA","Cardoner N","Zunta-Soares GB","Leibenluft E","Gold AL","Kostic M","Price RB","Sylvester CM","Myers M","Buckner R","Satterthwaite TD","Thompson PM","Critchley HD","Andreescu C","Cividini C","Agosta F","Ottaviani C","Stein MB","Pine DS","Strawn JR","Kaczkurkin AN","Assaf M","Yu Q","Salum GA","Zwiebel H","Lueken U","Burkhouse KL","Nielsen JA","Ernst M","Blair KS","Tamburo E","Bulow R","Zugman A","Harper J","Munjiza Jovanovic A","Straube T","Mujica-Parodi LR","Hilbert K","Gur RC","Werwath KE","Gur RE","Porta-Casteras D","Jahanshad N","Veltman DJ","Harrewijn A","Maggioni E","Wittfeld K","Salas R","Beesdo-Baum K","Milad MR","Manfro GG","Balderston NL","Bas-Hoogendam JM","Phan KL","van Nieuwenhuizen H","Canu E","Stein DJ","Thomopoulos SI","Ringlein GV","Mancini M","Perino MT","Blair JR","Jackowski AP","Schroeder HK","Freitag GF","Mwangi B","Hofmann D","Berta R"],"additional_accession":[]},"is_claimable":false,"name":"Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.","description":"The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5-90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ,","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-21T17:34:46.932Z","creation":"2025-04-21T17:34:46.932Z"},"accession":"S-EPMC8486763","cross_references":{"pubmed":["34599145"],"doi":["10.1038/s41398-021-01622-1"]}}