{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li RH"],"funding":["National Natural Science Foundation of China","NIGMS NIH HHS","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["1088-1105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8486796"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(10)"],"pubmed_abstract":["Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically"],"journal":["Cell research"],"pubmed_title":["A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling."],"pmcid":["PMC8486796"],"funding_grant_id":["81672791","82071567","81872300","R01 GM126048"],"pubmed_authors":["He XY","Liu J","Liu YZ","Yan Q","Li RH","Zhou T","Shao JZ","Shi CY","Xiong Y","Liu FZ","Yang ZZ","Li X","Lin A","Zhang Z","Ju HQ","Tian T","Wang LJ","Wang W","Ge QW","Li JH","Sang LJ"],"additional_accession":[]},"is_claimable":false,"name":"A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.","description":"Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T12:04:42.179Z","creation":"2025-04-04T12:04:42.179Z"},"accession":"S-EPMC8486796","cross_references":{"pubmed":["34267352"],"doi":["10.1038/s41422-021-00530-9"]}}