{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rustenhoven J"],"funding":["Washington University School of Medicine in St. Louis","NCATS NIH HHS","NCCIH NIH HHS","NIA NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["1000-1016.e27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8487654"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["184(4)"],"pubmed_abstract":["Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this surveillance. Here, we demonstrate that CNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T cells. This surveillance is enabled by endothelial and mural cells forming the sinus stromal niche. T cell recognition of CSF-derived antigens at this site promoted tissue resident phenotypes and effector functions within the dural meninges. These findings highlight the critical role of dural sinuses as a neuroimmune interface, where brain antigens are surveyed under steady-state conditions, and shed light on age-related dysfunction and neuroinflammatory attack in animal models of multiple sclerosis."],"journal":["Cell"],"pubmed_title":["Functional characterization of the dural sinuses as a neuroimmune interface."],"pmcid":["PMC8487654"],"funding_grant_id":["R37 AG034113","P30 CA091842","DP1 AT010416","UL1 TR002345","P41 GM103422","RF1 AG057496","UL1 TR000448","R01 AG034113"],"pubmed_authors":["Lemieux M","Baker W","Fitzpatrick J","Bayguinov P","Wall M","Drieu A","de Lima KA","Kanamori M","Zhang Q","Herz J","Dykstra T","Smirnov I","Salvador AF","Townsend RR","Papadopoulos Z","Kipnis J","Cugurra A","Lopes MB","Rustenhoven J","Mamuladze T","Kossina R","Sviben S","Da Mesquita S","Erdmann-Gilmore P"],"additional_accession":[]},"is_claimable":false,"name":"Functional characterization of the dural sinuses as a neuroimmune interface.","description":"Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this surveillance. Here, we demonstrate that CNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T cells. This surveillance is enabled by endothelial and mural cells forming the sinus stromal niche. T cell recognition of CSF-derived antigens at this site promoted tissue resident phenotypes and effector functions within the dural meninges. These findings highlight the critical role of dural sinuses as a neuroimmune interface, where brain antigens are surveyed under steady-state conditions, and shed light on age-related dysfunction and neuroinflammatory attack in animal models of multiple sclerosis.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-04-08T17:58:09.096Z","creation":"2025-04-05T22:21:44.307Z"},"accession":"S-EPMC8487654","cross_references":{"pubmed":["33508229"],"doi":["10.1016/j.cell.2020.12.040"]}}