biostudies-literatureUnknown16Hanbali AKing Faisal Specialist Hospital and Research Center<h4>Background</h4>Treating adolescents and young adults (AYA) patients with acute lymphoblastic leukemia (ALL) using pediatric-inspired protocols have shown improvement in outcomes. Most data available in the literature of such protocols is derived from well-controlled clinical trials. This report aims to provide a real-world experience from using a pediatric-inspired protocol in ALL-AYA population in larger number of patients treated at a national tertiary care referral center.<h4>Methods</h4>Newly diagnosed Philadelphia negative ALL-AYA patients ages between 14 and 55 years of age were treated on an institutional protocol (AYA-15 protocol) adopted from a modified version of Children's Cancer Group (CCG) 1900 protocol. At the time of this publication, a total of 79 patients were treated Leukemia research reports100270https://www.ebi.ac.uk/biostudies/studies/S-EPMC8488255biostudies-literatureImproved survival in adolescents and young adults (AYA) patients aged 14-55 years with acute lymphoblastic leukemia using pediatric-inspired protocol - a retrospective analysis of a real-world experience in 79 of patients treated at a national tertiary care referral center.PMC8488255Shaheen MAljurf MAlfraih FAlshaibani AAlsharif FAhmed SOChaudhri NAlhayli SRiash MAAsif MHanbali AAlahmari AAlotaibi ADeeba FRasheed WFakih REAlmohareb FKotb AAlzahrani HfalseImproved survival in adolescents and young adults (AYA) patients aged 14-55 years with acute lymphoblastic leukemia using pediatric-inspired protocol - a retrospective analysis of a real-world experience in 79 of patients treated at a national tertiary care referral center.<h4>Background</h4>Treating adolescents and young adults (AYA) patients with acute lymphoblastic leukemia (ALL) using pediatric-inspired protocols have shown improvement in outcomes. Most data available in the literature of such protocols is derived from well-controlled clinical trials. This report aims to provide a real-world experience from using a pediatric-inspired protocol in ALL-AYA population in larger number of patients treated at a national tertiary care referral center.<h4>Methods</h4>Newly diagnosed Philadelphia negative ALL-AYA patients ages between 14 and 55 years of age were treated on an institutional protocol (AYA-15 protocol) adopted from a modified version of Children's Cancer Group (CCG) 1900 protocol. At the time of this publication, a total of 79 patients were treated 2021-01-01T00:00:00Z20212025-04-19T21:38:56.2Z2022-02-11T12:01:24.817ZS-EPMC84882553463140710.1016/j.lrr.2021.100270