{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Chang YS"],"funding":["China Medical University Hospital"],"pubmed_abstract":["<h4>Background</h4>Long noncoding RNA (lncRNA) mediates the pathogenesis of various diseases, including cancer and cardiovascular, infectious, and metabolic diseases. This study examined the role of lncRNA <i>NTT</i> in the development and progression of cancer.<h4>Methods</h4>The expression of <i>NTT</i> was determined using tissues containing complementary DNA (cDNA) from patients with liver, lung, kidney, oral, and colon cancers. The expression of <i>cis-</i>acting genes adjacent to the <i>NTT</i> locus (<i>CTGF</i>, <i>STX7</i>, <i>MYB</i>, <i>BCLAF1</i>, <i>IFNGR1</i>, <i>TNFAIP3</i>, and <i>HIVEP2</i>) was also assessed. We used knockdown and chromatin immunoprecipitation (ChIP) assays to identify the <i>cis-</i>acting genes that interact with <i>NTT</i>.<h4>Results</h4><i>NTT</i> wa"],"journal":["Frontiers in oncology"],"pagination":["592045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8488295"],"repository":["biostudies-literature"],"pubmed_title":["Long Noncoding RNA <i>NTT</i> Context-Dependently Regulates <i>MYB</i> by Interacting With Activated Complex in Hepatocellular Carcinoma Cells."],"pmcid":["PMC8488295"],"pubmed_authors":["Lee YT","Chan WL","Chang JG","Lin LL","Yen JC","Chang WC","Chang YS","Chang YC","Lin SY"],"additional_accession":[]},"is_claimable":false,"name":"Long Noncoding RNA <i>NTT</i> Context-Dependently Regulates <i>MYB</i> by Interacting With Activated Complex in Hepatocellular Carcinoma Cells.","description":"<h4>Background</h4>Long noncoding RNA (lncRNA) mediates the pathogenesis of various diseases, including cancer and cardiovascular, infectious, and metabolic diseases. This study examined the role of lncRNA <i>NTT</i> in the development and progression of cancer.<h4>Methods</h4>The expression of <i>NTT</i> was determined using tissues containing complementary DNA (cDNA) from patients with liver, lung, kidney, oral, and colon cancers. The expression of <i>cis-</i>acting genes adjacent to the <i>NTT</i> locus (<i>CTGF</i>, <i>STX7</i>, <i>MYB</i>, <i>BCLAF1</i>, <i>IFNGR1</i>, <i>TNFAIP3</i>, and <i>HIVEP2</i>) was also assessed. We used knockdown and chromatin immunoprecipitation (ChIP) assays to identify the <i>cis-</i>acting genes that interact with <i>NTT</i>.<h4>Results</h4><i>NTT</i> wa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-07T20:31:30.658Z","creation":"2022-02-11T11:54:57.08Z"},"accession":"S-EPMC8488295","cross_references":{"pubmed":["34616668"],"doi":["10.3389/fonc.2021.592045"]}}