biostudies-literatureUnknown11Chang YSChina Medical University Hospital<h4>Background</h4>Long noncoding RNA (lncRNA) mediates the pathogenesis of various diseases, including cancer and cardiovascular, infectious, and metabolic diseases. This study examined the role of lncRNA NTT in the development and progression of cancer.<h4>Methods</h4>The expression of NTT was determined using tissues containing complementary DNA (cDNA) from patients with liver, lung, kidney, oral, and colon cancers. The expression of cis-acting genes adjacent to the NTT locus (CTGF, STX7, MYB, BCLAF1, IFNGR1, TNFAIP3, and HIVEP2) was also assessed. We used knockdown and chromatin immunoprecipitation (ChIP) assays to identify the cis-acting genes that interact with NTT.<h4>Results</h4>NTT waFrontiers in oncology592045https://www.ebi.ac.uk/biostudies/studies/S-EPMC8488295biostudies-literatureLong Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells.PMC8488295Lee YTChan WLChang JGLin LLYen JCChang WCChang YSChang YCLin SYfalseLong Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells.<h4>Background</h4>Long noncoding RNA (lncRNA) mediates the pathogenesis of various diseases, including cancer and cardiovascular, infectious, and metabolic diseases. This study examined the role of lncRNA NTT in the development and progression of cancer.<h4>Methods</h4>The expression of NTT was determined using tissues containing complementary DNA (cDNA) from patients with liver, lung, kidney, oral, and colon cancers. The expression of cis-acting genes adjacent to the NTT locus (CTGF, STX7, MYB, BCLAF1, IFNGR1, TNFAIP3, and HIVEP2) was also assessed. We used knockdown and chromatin immunoprecipitation (ChIP) assays to identify the cis-acting genes that interact with NTT.<h4>Results</h4>NTT wa2021-01-01T00:00:00Z20212026-05-07T20:31:30.658Z2022-02-11T11:54:57.08ZS-EPMC84882953461666810.3389/fonc.2021.592045